AUTHOR=Varela-Nieto Isabel , Murillo-Cuesta Silvia , Rodríguez-de la Rosa Lourdes , Oset-Gasque María Jesús , Marco-Contelles José 

TITLE=Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.711269

DOI=10.3389/fncel.2021.711269

ISSN=1662-5102

ABSTRACT=Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping oxygen and nitrogen reactive species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss has a heterogeneous aetiology, genetic alterations, ageing, toxins or exposure to noise can cause damage to the hearing receptor. Despite the many differences in the noxious stimuli there are several common mechanisms, being one of them the generation of free radicals and redox imbalance. Therefore, targeting oxidative stress-mediated hearing loss has been the subject of much attention. Here we review the chemistry of nitrones, the existing literature on their use as antioxidants and the general state of the art of antioxidant treatments for hearing loss.