AUTHOR=Beltran-Casanueva Rasiel , Hernández-García Aracelis , de Amo García Paula , Blanco-Reina Encarnación , Serrano-Castro Pedro , García-Casares Natalia , Fuxe Kjell , Borroto-Escuela Dasiel O. , Narváez Manuel 

TITLE=Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 18 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1323986

DOI=10.3389/fncel.2024.1323986

ISSN=1662-5102

ABSTRACT=This research demonstrates a sustained surge in neurogenesis within the dorsal dentate gyrus (DG) following intracerebroventricular injection of GALR2 and Y1R agonists.It is noted that co-delivering the M1145 GALR2 agonist and the Y1R agonist spurred neuroblast proliferation involving a protein in replication processes (PCNA+) and doublecortin (DCX+), a microtubule associated protein. However, quiescent neural progenitors and astrocytes remained unaffected.The study reveals a rise in putative Y1R-GALR2 heteroreceptor complexes.Significant enhancement in object-in-place memory consolidation was seen after a three-week treatment, hinting at a significant combined role of GalR2 and Y1R receptors in memory consolidation involving a putative formation of a Y1R-GalR2 heterocomplex, It may offer a promising avenue for future treatment strategies of learning and memory