AUTHOR=Condon Claire , Careta-Borràs Oriol , Fodor Judit , Al Riyami Amani B. , Xiao Xiao , Zhao Jianzhang , Nogués Carme , Draper Sylvia M. 

TITLE=Preliminary investigation of Ru(II) complexes bearing nile red chromophores for photodynamic therapy

JOURNAL=Frontiers in Chemical Biology

VOLUME=Volume 4 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/chemical-biology/articles/10.3389/fchbi.2025.1620562

DOI=10.3389/fchbi.2025.1620562

ISSN=2813-530X

ABSTRACT=Two previously investigated Ru(II) triplet photosensitisers (PS) ([Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2]) comprising a bipyridyl frame and acetylene appended Nile red chromophore, were converted to their chloride salts for cytotoxicity and phototoxicity measurements. SKBR3-cell lines were used to evaluate the photodynamic activity of the compounds. Irradiation (λex 630 nm; 15 min; 33 J cm−2) at a non-toxic concentration of 10 nM, [Ru-2ENR][(PF6)2] and [Ru-3ENR][(PF6)2] induced a reduction in metabolic activity by 60% and 30% respectively.