AUTHOR=Hervé Gwénaëlle , Len Christophe 

TITLE=Aqueous microwave-assisted cross-coupling reactions applied to unprotected nucleosides

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 3 - 2015

YEAR=2015

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2015.00010

DOI=10.3389/fchem.2015.00010

ISSN=2296-2646

ABSTRACT=Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C7- or C8-modified purines have mostly been prepared using palladium cross-coupling reactions and then studied as antitumoral and antiviral agents. Our objective is to focus this review on the Suzuki-Miyaura and on the Heck cross-couplings of nucleosides using microwave irradiations which are an alternative technology compatible with green chemistry and sustainable development.