AUTHOR=Mioc Marius , Avram Sorin , Bercean Vasile , Kurunczi Ludovic , Ghiulai Roxana M. , Oprean Camelia , Coricovac Dorina E. , Dehelean Cristina , Mioc Alexandra , Balan-Porcarasu Mihaela , Tatu Calin , Soica Codruta 

TITLE=Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 6 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2018.00373

DOI=10.3389/fchem.2018.00373

ISSN=2296-2646

ABSTRACT=A series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, obtained by docking based virtual screening (DBVS) of a previous constructed compound library, were synthesized and evaluated for their biological activities on a colorectal cancer cell line, HT-29. Among all synthesized compounds, TZ55.7, which was retained as a possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor cell line. The same compound alongside other two, TZ53.7 and TZ3a.7, led to a significant cell cycle arrest in both sub G0/G1 and G0/G1 phase. This study provides future perspectives for the development of new agents containing the 1,2,4-mercapto triazole scaffold with antiproliferative activities in colorectal cancer.