AUTHOR=Mujeeb Anzar Abdul , Alam Khan Farheen Badre , Alshameri Ansam Wadia Faid , Jamal Fauzia , Farheen Saba , Kashif Mohd , Ahmed Anees , Ghazi Irfan Ahmad , Owais Mohammad 

TITLE=Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 7 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00787

DOI=10.3389/fchem.2019.00787

ISSN=2296-2646

ABSTRACT=In general, neurodegenerative disorders have great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules. Among various species formed during aggregation process, protein oligomers have been classified as most toxic entities against several types of living cells. A series of chemicals have been developed to inhibit protein aggregation as a measure to regulate neurodegenerative diseases. Recently, various types of nanoparticles have also been reported as potent inhibitors of protein aggregation.   In the present study, we synthesised fluorescent gold nanoparticles (B-AuNPs) employing Olax scandens leaf extract.  Next, we executed an in vitro study to elucidate the effect of as-synthesized B-AuNPs on the aggregation behaviour of the ovalbumin (OVA), a model protein. We performed extensive study to elucidate anti-amyloidogenic properties of nano-sized entities and established that small sized B-AuNPs manifest chaperone potential against protein aggregation. Further, we exploited as-synthesised B-AuNPs in prevention of   protein aggregation mediated toxicity to neuroblastoma cells.