AUTHOR=Wang Dong , Ma Xinyue , Dong Linru , Feng Hairong , Yu Peng , Désaubry Laurent TITLE=Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles JOURNAL=Frontiers in Chemistry VOLUME=Volume 7 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00810 DOI=10.3389/fchem.2019.00810 ISSN=2296-2646 ABSTRACT=We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position. Notably, the utility of this method was demonstrated with the efficient construction of pharmaceutically relevant products.