AUTHOR=Dwivedi Kartikey Dhar , Borah Biplob , Chowhan L. Raju 

TITLE=Ligand Free One-Pot Synthesis of Pyrano[2,3-c]pyrazoles in Water Extract of Banana Peel (WEB): A Green Chemistry Approach

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 7 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00944

DOI=10.3389/fchem.2019.00944

ISSN=2296-2646

ABSTRACT=Here, we have developed a novel, simple, efficient and green protocol for one-pot synthesis of pyrano[2,3-c]pyrazole by utilizing arylidene malononitrile and pyrazolone in  Water Extract of Banana Peels (WEB) as a reaction medium at room temperature.  This is a green and general synthetic protocol without using any toxic organic solvent, ligand, base which could be applicable for a wide range of substrate scope. This protocol has advantages of good to excellent yields, fast reactions, eco-friendly reaction conditions, easy isolation of the product without using column chromatography. The green chemistry matrices calculation like atom economy reaction, environmental factor, as well as process mass intensity indicates the eco-friendly nature of the protocol.