AUTHOR=Radisavljević Snežana , Petrović Biljana 

TITLE=Gold(III) Complexes: An Overview on Their Kinetics, Interactions With DNA/BSA, Cytotoxic Activity, and Computational Calculations

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 8 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00379

DOI=10.3389/fchem.2020.00379

ISSN=2296-2646

ABSTRACT=In the last few years metallodrugs play the key role in the development of medicinal chemistry. The choice of metal ion, its oxidation state, stability, the choice of inert and labile ligands are just some of the very important facts which must be considered before starting the synthesis of complexes with utilization in medicinal purpose. As a result, a lot of compounds of different transition metal ions found application for diagnostic and therapeutic purpose. Beside all, gold compounds have attracted particular attention. It is well known that gold compounds could be used for the treatment of cancer, HIV, rheumatoid arthritis (chrysotherapy) and other diseases. This metal ion has unoccupied 
d-sublevels and possibility to form compounds with different oxidation states, from -1 to +5. However, gold(I) and gold(III) complexes are dominant in chemistry and medicine. Especially, gold(III) complexes are of the great interest due to their structural similarity with cisplatin. Accordingly, this review summarize the chemistry of some mononuclear and polynuclear gold(III) complexes. Special attention is given to gold(III) complexes with nitrogen-donor inert ligands (aliphatic or aromatic that have a possibility to stabilize complex) and their kinetic behavior toward different biologically relevant nucleophiles, mechanism of interaction with DNA/BSA, cytotoxic activity as well as computational calculations.