AUTHOR=Feng Huayang , Chu Dandan , Yang Fan , Li Zhanrong , Fan Bingbing , Jin Lin , Li Jingguo 

TITLE=Hypoxia-Responsive Polymeric Micelles for Enhancing Cancer Treatment

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 8 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.00742

DOI=10.3389/fchem.2020.00742

ISSN=2296-2646

ABSTRACT=Polymer drug vectors have shown great potentials in tumor therapy. However, intelligently controlled release of drug has become a major challenge in nanomedicine research. Hypoxia-responsive polymer micelles have received widespread attention in recent years due to the inherent hypoxic state of tumor tissue. In this study, a novel diblock polymer consisting of polyethylene glycol and poly(glutamic acid (3-(2-nitro-imidazolyl)-propyl)) was synthesized and self-assembled into hypoxia-responsive polymeric micelles for the control-release of chemotherapy drugs. The cell experiments demonstrated that DOX-loaded micelles had a stronger killing capacity on tumor cells under hypoxic conditions, while the blank micelles did not have cytotoxicity. All the experiments indicate that our hypoxia-responsive polymeric micelles have a potential for enhanced cancer treatment.