AUTHOR=Chen Lujia , Chen Meijuan , Zhou Yuping , Ye Changsheng , Liu Ruiyuan 

TITLE=NIR Photosensitizer for Two-Photon Fluorescent Imaging and Photodynamic Therapy of Tumor

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.629062

DOI=10.3389/fchem.2021.629062

ISSN=2296-2646

ABSTRACT=Preparation of near-infrared (NIR) emissive fluorophore for imaging-guided photodynamic therapy has attracted enormous attention.  Hence, NIR emissive fluorophore of two-photon fluorescence imaging, and photoactive cancer cells apoptosis are highly desirable.  In this study, a novel D-pai-A structured NIR photosensitizer (TTRE) is synthesized.  TTRE demonstrates near-infrared (NIR) emission, good biocompatibility, and superior photostability, which can act as two-photon fluorescent agent for clear visualization of living cells and vascular in tissues with deep-tissue penetration.  The efficacy of TTRE as photosensitizer is exploited in vitro and in vivo.  All these results confirm that TTRE can serve as potential platform for two-photon fluorescent imaging of cells/tissues and photodynamic therapy.