AUTHOR=Guo Yeting , Ying Jianxi , Sun Dongru , Zhang Yumeng , Zheng Minyang , Ding Ruiwen , Liu Yan , Zhao Yufen 

TITLE=Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.675821

DOI=10.3389/fchem.2021.675821

ISSN=2296-2646

ABSTRACT=Cyclic dipeptides (DKPs) are considered as peptide precursors and chiral catalysts in the prebiotic process. Here we report proline-containing DKPs spontaneously obtained from linear dipeptides under aqueous solution. Significantly, the yields of DKPs were affected by sequence of linear dipeptides and whether reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.