AUTHOR=Hu Meigeng , Zhao Dan , Xu Xudong , Ma Guoxu , Wu Haifeng , Chen Xi 

TITLE=Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.695456

DOI=10.3389/fchem.2021.695456

ISSN=2296-2646

ABSTRACT=Phytochemical studies on the rhizomes of Actaea asiatica led to the isolation of seven new cycloartane triterpenes, actaticas A−G (1−7). Their structures were determined by NMR, HRESIMS and chemical analysis All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity,All compounds showed significant inhibitory effects with IC50 values of 9.2 - 26.4 μM.