AUTHOR=Wu Mingzhou , He Shuqing , Hu Xin , Chen Jingqin , Ha Enna , Ai Fujin , Ji Tao , Hu Junqing , Ruan Shuangchen 

TITLE=A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.695511

DOI=10.3389/fchem.2021.695511

ISSN=2296-2646

ABSTRACT=Transition-metal chalcogenides compound with both facile preparation and multifunctional element are strongly desired to act as ideal photothermal agents for cancer theranostics. Herein, this work synthesize interesting Cu7.2S4/5MoS2 composite nanoflowers and investigate the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu7.2S4/5MoS2 exhibit a high photothermal conversion efficiency of 58.7% and work as a theranostic nanoplatform and demonstrated an effective photothermal-chemodynamic-photodynamic synergetic therapeutic effect both in vitro and in vivo tests. Moreover, Cu7.2S4/5MoS2 show strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These inspired results suggest the great potential application of Cu7.2S4/5MoS2 composite nanoflowers as a photo/H2O2-responsive therapeutic-agent against tumors.