AUTHOR=Yu Ronglu , Liu Jia , Wang Yi , Wang Hong , Zhang Huawei 

TITLE=Aspergillus niger as a Secondary Metabolite Factory

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.701022

DOI=10.3389/fchem.2021.701022

ISSN=2296-2646

ABSTRACT=Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covered agriculture, food and pharmaceutical industry. By extensive literature search, this review makes a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs and secondary metabolites as well as biological properties and biosynthetic pathways. Future perspectives in the discovery of more A. niger-derived functional biomolecules are also provided in this review