AUTHOR=Zheng Lin Lin , Li Jin Ze , Li Ying Xu , Gao Jian Bang , Dong Jiang Xue , Gao Zhong Feng 

TITLE=pH-Responsive DNA Motif: From Rational Design to Analytical Applications

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.732770

DOI=10.3389/fchem.2021.732770

ISSN=2296-2646

ABSTRACT=pH-Responsive DNA motif have attracted substantial attention attributed to its high designability and versatility of DNA chemistry. Such DNA motif typically exploit DNA secondary structures that exhibit pH response properties because of the presence of specific protonation sites. In this review, we briefly summarized second structure-based pH-responsive DNA motif, including triplex, i-motif and A-C mismatch base pair-based DNA devices. Finally, remaining challenge and prospect of pH-responsive DNA motif are also discussed.