AUTHOR=Xiao Lizhi , Hui Fang , Tian Tenghui , Yan Ruyue , Xin Jingwei , Zhao Xinyu , Jiang Yingnan , Zhang Zhe , Kuang Yulan , Li Na , Zhao Yu , Lin Quan 

TITLE=A Novel Conductive Antibacterial Nanocomposite Hydrogel Dressing for Healing of Severely Infected Wounds

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.787886

DOI=10.3389/fchem.2021.787886

ISSN=2296-2646

ABSTRACT=Wound infections are serious medical complications that can endanger human health. To accelerate infected wound healing, a novel medical silver nanoparticle/polymer-based hydrogel (Ag NPs/CPH) dressing with good conductivity, biocompatibility, and mechanical and antibacterial properties was fabricated. For the hydrogel dressing, Ag NPs/CPH, polyvinyl alcohol (PVA), and gelatin were used as the host matrix materials, and phytic acid (PA) was used as the cross-linking agent to introduce conductive polyaniline into the matrix, with antibacterial Ag NPs loaded via impregnation. In addition, a novel and innovative infection and inflammation model was designed to evaluate the prepared Ag NPs/CPH hydrogel dressing for the severely infected wounds treatment. The results showed that even when infected with bacteria for long periods of time, the proposed conductive antibacterial hydrogel could treat severely infected wounds. Thus, this medical hydrogel dressing holds great application potential.