AUTHOR=Zhu Youjuan , Kong Yichao , Hong Yu , Zhang Ling , Li Simin , Hou Shurong , Chen Xiabin , Xie Tian , Hu Yang , Wang Xiachang 

TITLE=Huoshanmycins A‒C, New Polyketide Dimers Produced by Endophytic Streptomyces sp. HS-3-L-1 From Dendrobium huoshanense

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.807508

DOI=10.3389/fchem.2021.807508

ISSN=2296-2646

ABSTRACT=Three new polyketide dimers, huoshanmycins A‒C (1‒3), were reported from the fermentation broth of Streptomyces sp. HS-3-L-1, an endophyte isolated from the leaf of Dendrobium huoshanense. The dimeric structures of huoshanmycins were composed of SEK43, SEK15 or UWM4, with a unique methylene linkage. Their structures were elucidated through comprehensive 1D-/2D-NMR and HRESIMS spectroscopic data analysis. Huoshanmycins A and B (1, 2) displayed moderate cytotoxicity against MV4-11 human leukemia cell.