AUTHOR=Tang Jun , Huang Xueshuang , Cao Ming-Hang , Wang Zhiyan , Yu Zhiyin , Yan Yijun , Huang Jian-Ping , Wang Li , Huang Sheng-Xiong 

TITLE=Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.812564

DOI=10.3389/fchem.2021.812564

ISSN=2296-2646

ABSTRACT=Guiding by an antifungal screening, seven mono-/bis-alkenoic acid derivatives (1‒7) were isolated from an endophytic fungi Scopulariopsis candelabrum. Their chemical structures were identified by 1H-NMR, 13C-NMR, 2D NMR and high-resolution mass spectrometry, as well as comparisons with previously reported literatures. Among them, fusariumesters C-F (2‒5) are bis-alkenoic acid derivatives dimerized by an ester bond, while acetylfusaridioic acid A (6) and fusaridioic acid D (7) are alkenoic acid monomers. All the isolates were submitted to an antifungal assay against Candida albicans. Resultly, compound 1 decorating with β-lactone ring turned out to be active with a MIC value of 20 μg/mL.