AUTHOR=Han Dong , Liu Yan , Li Xiao-Mao , Wang Si-Yi , Sun Yan , Algradi Adnan Mohammed , Zou Hai-Dan , Pan Juan , Guan Wei , Kuang Hai-Xue , Yang Bing-You 

TITLE=Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 9 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.813764

DOI=10.3389/fchem.2021.813764

ISSN=2296-2646

ABSTRACT=Elesesterpenes A-K (1-11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid, were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A-B (1-2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and anti-proliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent anti-proliferative activities.