AUTHOR=Rao Kairui , Chai Zhangmengjie , Zhou Pan , Liu Donghan , Sun Yulin , Yu Fuchao 

TITLE=Transition-metal-free approach to quinolines via direct oxidative cyclocondensation reaction of N,N-dimethyl enaminones with o-aminobenzyl alcohols

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1008568

DOI=10.3389/fchem.2022.1008568

ISSN=2296-2646

ABSTRACT=A transition-metal-free method for the construction of 3-substituted or 3,4-disubstituted quinolines from readily available N,N-dimethyl enaminones and o-aminobenzyl alcohols is reported. The direct oxidative cyclocondensation reaction tolerates broad functional groups, allowing the efficient synthesis of various quinolines in moderate to excellent yields. The reaction involves a C(sp3)-O bond cleavage and a C=N bind and a C=C bond formations during the oxidative cyclization process and the mechanism was proposed.