AUTHOR=Han XiaoLe , Yu Fan , Lei JiaWen , Zhu Jiahua , Fu HaiYan , Hu JunCheng , Yang Xiao-Long 

TITLE=Pb2+ Responsive Cu-In-Zn-S Quantum Dots With Low Cytotoxicity

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.821392

DOI=10.3389/fchem.2022.821392

ISSN=2296-2646

ABSTRACT=Water-soluble Cu-In-Zn-S quantum dots (CIZS QDs) with orange fluorescence have been synthesized with a glutathione (GSH) as stabilizer via facile a one-step hydrothermal method. The optimal reaction conditions of CIZS QDs including temperature, time, pH and the molar ratios of precursors were studied. According to observation results of TEM, the aqueous-dispersible CIZS QDs are quasi-spherical and the average diameters are 3.76 nm with excellent fluorescent stability. Furthermore, the cytotoxicity of CIZS QDs was investigated by the microcalorimetry combining with TEM and the IC50 was 10.2 uM. CIZS QDs showed a promising perspective in applications such as a fluorescent probe for bioimaging and biolabeling due to the low toxicity and good biocompatibility. Moreover, the CIZS QDs can distinguish Pb2+ ion from other ions, offering great potentials in lead ion determination in drink water. According to the results of UV, XRD, FL, PL and ITC methods, CIZS QDs was developed for Pb2+ assay and promising quenching mechanism.