AUTHOR=Liu Yan , Jiang Peng , Zhang Mei-Ling , Pan Juan , Guan Wei , Li Xiao-Mao , Yang Bing-You , Kuang Hai-Xue 

TITLE=Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.825763

DOI=10.3389/fchem.2022.825763

ISSN=2296-2646

ABSTRACT=Five previously undescribed oleanane-type triterpenoid saponins (1-5), together with twenty-four known saponins (6-29) were isolated from the fruit of Acanthopanax senticosus. The structures of all compounds were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS, in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by LPS-induced BV2 microglia, and the neuroprotective effects of all compounds (1-29) were evaluated.