AUTHOR=Chen De , Lu Hao , Liu Yuxuan , Deng Wei , Qiu Renhua , Xiang Jiannan TITLE=One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions JOURNAL=Frontiers in Chemistry VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.825772 DOI=10.3389/fchem.2022.825772 ISSN=2296-2646 ABSTRACT=A simple and efficient one-pot three-component cascade reaction of α-amino carbonyl compounds, indoles and CBr4 in moderate to good yields has been developed. This new strategy exhibits excellent mild reaction conditions and step-economy, easily accessible reactiants and simultaneous construction of three different new bonds (C=N, C–C, and N-Br) in a single step. It is worth noting that the protocol developed provides a simple and practical tool for the construction of diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.