AUTHOR=Yang Min , Wu Chao , Zhang Tianxi , Shi Lei , Li Jian , Liang Hongbao , Lv Xuzhen , Jing Fengtang , Qin Lu , Zhao Tianlun , Wang Chenxi , Liu Guangxu , Feng Shuai , Li Feng 

TITLE=Chicoric Acid: Natural Occurrence, Chemical Synthesis, Biosynthesis, and Their Bioactive Effects

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.888673

DOI=10.3389/fchem.2022.888673

ISSN=2296-2646

ABSTRACT=Chicoric acid (CA) has been widely used in food, medicine, animal husbandry and other different commercial products because of its significant pharmacological activities. However, the shortage of chicoric acid limits its further development and utilization. At present, Echinacea purpurea is widely used as the main natural source of chicoric acid, while other sources of it are poorly known. Extracting chicoric acid from plants is the most common approach. Meanwhile, the content of chicoric acid varies in different plants and the same plant from different producing areas and in different medicinal parts and with different extraction methods. Thus, we reviewed a comprehensive information about the sources of chicoric acid from plant extracts, chemical synthesis, biosynthesis and bioactive effects to explore an advantage path of chicoric acid for further study.