AUTHOR=Lu Xin-Yang , Li Jing , Kong Fen-Ying , Wei Mei-Jie , Zhang Pei , Li Ying , Fang Hai-Lin , Wang Wei 

TITLE=Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.892919

DOI=10.3389/fchem.2022.892919

ISSN=2296-2646

ABSTRACT=An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide-TiO2-Au nanocomposites modified glassy carbon electrode (rGO-TiO2-Au/GCE). Transmission electron microscopy, X-ray diffractometer and X-ray photoelectron spectroscopy were employed to confirm the morphology, structure and composition properties of the rGO-TiO2-Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO-TiO2-Au/GCE for ACV. As a result, rGO-TiO2-Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µL. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1-100 µM and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.