AUTHOR=Bose Ashmita , Dittrich Peter , Gorecki Jerzy 

TITLE=The Concilium of Information Processing Networks of Chemical Oscillators for Determining Drug Response in Patients With Multiple Myeloma

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.901918

DOI=10.3389/fchem.2022.901918

ISSN=2296-2646

ABSTRACT=It can be expected that the medical treatment in the future will be individually tailored for each
 patient. Here we present a step towards personally addressed drug therapy. We consider multiple
 myeloma treatment with the drug named Bortezomib. It has been observed that this drug is
 effective for some patients and does not help others. We describe a network of chemical oscillators
 that can help to differentiate between non-responsive and responsive patients. In our numerical
 simulations, we consider a network of 3 interacting oscillators described with the Oregonator
 model. The input information is the gene expression value for one of 15 genes measured for
 patients with multiple myeloma. The single-gene networks optimized on a training set containing
 data of 239 therapies show up to 71% accuracy of differentiating between non-responsive and
 responsive patients. If the results of single-gene networks are combined into the concilium with
 the majority voting strategy, then the accuracy of predicting the patient’s response to Bortezomib
 therapy increases to ∼ 85 %.