AUTHOR=Xie Dandan , Hu Xin , Ren Xiaoli , Yang Zaiping TITLE=Synthesis and Bioactivities of Novel Piperonylic Acid Derivatives Containing a Sulfonic Acid Ester Moiety JOURNAL=Frontiers in Chemistry VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.913003 DOI=10.3389/fchem.2022.913003 ISSN=2296-2646 ABSTRACT=The crop loss caused by bacteria has increased year by year due to the lack of effective control agents. In order to develop efficiency, broad-spectrum, and structure simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives containing a sulfonic acid esters moiety was synthesized. Bioassay results indicated the compounds exhibited significantly antibacterial activities. Among them, compound 41 exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99% and 85% at 100 μg/mL and 50 μg/mL, respectively, which was higher than thiodiazole-copper (84% and 77%) and bismerthiazol (96% and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above results confirm the broadening of the application of piperonic acid, which eliable support for the development of novel agrochemical bactericide.