AUTHOR=Xiao Shu , Ai Likun , Liu Qichang , Yang Baihui , Huang Jian , Xue Wei , Chen Yang 

TITLE=Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.941184

DOI=10.3389/fchem.2022.941184

ISSN=2296-2646

ABSTRACT=Transition metal catalysis plays an important role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a key or secondary step in the total synthesis of natural products, especially terpenoids. Terpenoids represent one of the largest families among various categories of natural products, arousing the interest of scientists from different research fields based on its important physiological activity. The review summarizes the recent advanced toward total synthesis of terpenoids by cobalt-mediated asymmetric catalysis.