AUTHOR=Sasaki Yui , Lyu Xiaojun , Minami Tsuyoshi 

TITLE=Printed colorimetric chemosensor array on a 96-microwell paper substrate for metal ions in river water

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1134752

DOI=10.3389/fchem.2023.1134752

ISSN=2296-2646

ABSTRACT=We herein propose a printed 96-well microtiter paper-based chemosensor array device (PCSAD) to detect metal ions simultaneously toward river water assessment. The colorimetric chemosensors for metal ions have been designed based on molecular self-assembly with off-the-shelf catechol dyes and a phenylboronic acid (PBA) derivative. The colorimetric self-assembled chemosensors consisting of the catechol dyes and the PBA derivative on the 96-well microtiter paper substrate have shown various color changes according to the disassembly of the ensembles by the addition of the target nine types of metal ions. An in-house-made algorithm has performed automated imaging analysis to extract color intensities at seven types of color channels from the captured digital image, allowing rapid data processing. The obtained information-rich inset data showing the fingerprint-like colorimetric responses has been applied to qualitative and quantitative pattern recognition of metal ions through chemometric techniques. The feasibility of the 96-well microtiter PCSAD for environmental assessment has been revealed by the demonstration of a spike and recovery test against metal ions in a river water sample.