AUTHOR=Patsula Vitalii , Mareková Dana , Jendelová Pavla , Nahorniak Mykhailo , Shapoval Oleksandr , Matouš Petr , Oleksa Viktoriia , Konefał Rafał , Vosmanská Magda , Machová-Urdziková Lucia , Horák Daniel 

TITLE=Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1207984

DOI=10.3389/fchem.2023.1207984

ISSN=2296-2646

ABSTRACT=Large (120 nm) hexagonal NaYF4:Yb,Er nanoparticles (UCNPs) were synthesized by hightemperature coprecipitation method and coated with poly(ethylene glycol)-alendronate (PEG-Ale), poly(N,N-dimethylacrylamide-co-2-aminoethylacrylamide)-alendronate (PDMA-Ale) or poly(methyl vinyl ether-co-maleic acid) (PMVEMA). The colloidal stability of polymer-coated UCNPs in water, PBS and DMEM medium was investigated by dynamic light scattering; UCNP@PMVEMA particles showed the best stability in PBS. Dissolution of the particles in water, PBS, DMEM and artificial lysosomal fluid (ALF) determined by potentiometric measurements showed that all particles were relatively chemically stable in DMEM.