AUTHOR=Melchiorre Giulia , Giustiniano Francesco , Rathore Sundeep , Pileio Giuseppe 

TITLE=Singlet-assisted diffusion-NMR (SAD-NMR): extending the scope of diffusion tensor imaging via singlet NMR

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 11 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1224336

DOI=10.3389/fchem.2023.1224336

ISSN=2296-2646

ABSTRACT=Long-lived nuclear singlet order methods are here combined with diffusion tensor imaging with the purpose of characterizing the full diffusion tensor of molecules that freely diffuse in large pores of up to the millimeter. Such sizes are out-of-reach to conventional diffusion tensor imaging because of the limitations imposed by the relaxation decay constant of the longitudinal magnetization. A singlet-assisted diffusion tensor imaging methodology able to circumvent such limitations is discussed and the new possibilities it offers are demonstrated through simulation and experiments on plastic phantoms containing cylindrical channels of onemillimeter diameter.