AUTHOR=Abdulkadhim Adnan Hashim , Husein Kamona Suhair Mohammad , Shamikh Al-Saedi Haider Falih , Taki Anmar Ghanim , Hamoody Abdul-Hameed. M. , Hamood Sarah A. , Rab Safia Obaidur , Amir Ahmed Ali , Kareem Ashwaq Talib , Alawadi Ahmed , Ihsan Ali 

TITLE=Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 11 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1331933

DOI=10.3389/fchem.2023.1331933

ISSN=2296-2646

ABSTRACT=Recently, nanoscience, especially metal-organic frameworks MOFs, has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation and penicillin, which is a known antibiotic, and copper metal-organic frameworks (Cu-MOF), a new penicillinoate@copper metal-organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were done using FT-IR spectrums, EDAX analysis, elemental analysis, XRD pattern, SEM and images, nitrogen adsorption/desorption curve, and TGA curve. Then, its antimicrobial effects were evaluated on numerous Gram-positive and Gram-negative bacterial strains and were compared with penicillin and gentamicin. In continuation of the biological activities, antioxidant tests were performed on the compounds using the DPPH method. In biological activities, the synthesized penicillinoate@Cu-MOF is much more effective than penicillin and Cu-MOF. The loading of penicillin on the nanostructure and the presence of copper in the final composition can be attributed to the high antibiotic properties of the synthesized composition.