AUTHOR=Wissner Julian L. , Almeida Joana R. , Grilo Inês R. , Oliveira Jhenifer F. , Brízida Carolina , Escobedo-Hinojosa Wendy , Pissaridou Panayiota , Vasquez Marlen I. , Cunha Isabel , Sobral Rita G. , Vasconcelos Vítor , Gaudêncio Susana P. 

TITLE=Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2024.1425953

DOI=10.3389/fchem.2024.1425953

ISSN=2296-2646

ABSTRACT=Biofouling presents a significant economic threat to various marine industries, resulting in substantial financial losses that can amount to billions of euros annually. This study addresses the pressing need for effective alternatives to traditional antifouling agents, especially in the aftermath of the global prohibition of organotin compounds.Our research highlights the importance of madeirone (1), a novel marinone derivative discovered in the framework of this study, and neomarinone (2), both isolated from Streptomyces aculeolatus PTM-346, as potent inhibitors of both micro and macrofouling marine species. Madeirone (1) displayed significant antibiofilm efficacy inhibition against Phaeobacter inhibens (up to 66%),