AUTHOR=Shi Ying-Chu , Yu Yu-Xin , Gao Jiu-Xia , Wang Xin , Shang Xiao-Ya , Xu Jia 

TITLE=Iridoid glycoside dimers from fruits of Cornus officinalis and their anti-inflammatory activity

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2025.1558075

DOI=10.3389/fchem.2025.1558075

ISSN=2296-2646

ABSTRACT=A bioassay-guided phytochemical study of the fruits of Cornus officinalis led to the isolation of six new iridoid glycoside dimers, named corndiridoside A-F (1–6), along with 11 analogs (7–17). The structure of these dimers was elucidated using HRESIMS, 1D and 2D NMR, IR, and UV spectra, as well as literature comparisons. The anti-inflammatory activity of all compounds was evaluated, revealing a significant inhibitory effect on all dimers on the production of NO in LPS-stimulated RAW 264.7 cells at concentrations of 25 and 50 μM. Of the six, compounds 2 and 3 showed the strongest anti-inflammatory activity.