AUTHOR=Li Rourou , Zhang Guanjun , Yu Shuyan , Deng Ruyv , Yin Jiechun , Zhang Taijun , He Qiuxing 

TITLE=Impact of molecular structures of lauroyl glycine derivatives on foaming properties

JOURNAL=Frontiers in Chemistry

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2025.1563560

DOI=10.3389/fchem.2025.1563560

ISSN=2296-2646

ABSTRACT=IntroductionThis investigation systematically elucidates the foam dynamics and consumer perception correlations within amino-acid-derived surfactant-mixedcomponent systems.MethodspH-gradient experiments (5.5–10) combined with dynamic foam analysis were employed to quantify foam nucleation kinetics. Molecular dynamics simulations analyzed intermolecular interactions, while lipid resistance evaluations measured cleaning efficiency.ResultsSLG-CAB blends accelerated foam nucleation from 35 s to 20 s/100 mL (pH=8.5), outperforming commercial benchmarks (<5 s initial formation) with statistical significance. Robust hydrogen bonds between CAB’s ammonium protons and SLG’s carboxamide oxygen (bond length: 1.901 Å) achieved thermodynamic stabilization (ΔE = –53.04 kcal/mol), enhancing film stability (Tfls 50% > 5 min). SLG-CAB generated monodisperse bubbles (diameter ≈95 μm), imparting “velvety” sensory properties, with 74.74% lipid cleaning efficiency at pH 7–8 (synergistic coefficient βs = –2.822).DiscussionThe SLG-CAB system demonstrates synergistic foam enhancement and lipid resistance, enabling “prolonged creaminess” in cleansing applications. Bridging cosmetic applications (facial cleansers, body washes) with surfactant engineering principles, this work establishes phase behavior-guided formulation strategies for personal care products.