There was a mistake in the caption of Figure 3 as published. There were missing values. The corrected caption appears below.
FIGURE 3 | Comprehensive characterization of Rhein-mediated selenium nanoparticles (Rhein-SeNPs). (A) Transmission electron microscopy (TEM) image showing spherical nanoparticles with uniform distribution and an average diameter of 32 ± 5 nm. (B) Atomic force microscopy (AFM) confirming the nanoscale height profile and surface morphology. (C) Dynamic light scattering (DLS) analysis indicating an average hydrodynamic size of 90.4 nm with a narrow size distribution. (D) Zeta potential measurement showing a surface charge of −31.1 mV, suggesting good colloidal stability. (E) X-ray diffraction (XRD) pattern confirming the crystalline/semi-crystalline nature of the synthesized SeNPs.
The two mentions of XPS were inadvertent errors.
A correction has been made to section 1 Introduction, paragraph 7. The corrected sentence reads:
“Our formulation advances the field through four distinct innovations: first, employing pure, NMR-characterized rhein rather than crude extracts; and second, ensuring reproducible synthesis and defined molecular interactions, as confirmed by FTIR spectroscopy.”
A correction has been made to section 3 Results, “3.1 Characterization of rhein and Rh-Se-NPs,” paragraph 16. The corrected sentence reads:
“These STEM-EDX findings provide spatial confirmation of core-shell architecture with selenium core and rhein organic shell, validating the proposed nanoparticle structure and complementing the FTIR surface characterization.”
The value 104 was incorrectly displayed as 10^4, and the words “from soybean, chickpea, and lupin” were erroneously included. A correction has been made to section 2 Materials and methods, “2.7 In vitro cytotoxicity”, 2.7.2 MTT-assay, paragraph 1. The corrected sentence reads:
“Cells 1.0 × 104 were seeded in 96-well plates for 24 h, then treated with Rhein or Rhein-NPs (150 μL/well) at concentrations of 800 to 25 μg/mL; controls received PBS.”
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
apoptosis induction, caspase-3 and caspase-9 activation, colon cancer therapy, gene expression modulation, green synthesis, oncogene suppression, rhein-selenium nanoparticles
Citation
Abd El-Halim MD, Osman A, Ibrahim MA, El-Azab MM, El-Saber MM, Ismail SH, Roshdy T, Sitohy M and Sitohy B (2026) Correction: Green-synthesized rhein-selenium nanoparticles exhibit potent and highly selective anticancer activity against colon cancer via apoptosis and gene regulation. Front. Chem. 14:1960735. doi: 10.3389/fchem.2026.1960735
Received
06 August 2026
Accepted
11 August 2026
Published
27 August 2026
Volume
14 - 2026
Edited and reviewed by
Marta De Zotti, University of Padua, Italy
Updates
Copyright
© 2026 Abd El-Halim, Osman, Ibrahim, El-Azab, El-Saber, Ismail, Roshdy, Sitohy and Sitohy.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Basel Sitohy, basel.sitohy@umu.se
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.