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        <title>Frontiers in Chemistry | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/chemistry</link>
        <description>RSS Feed for Frontiers in Chemistry | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-06T12:17:20.819+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1796912</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1796912</link>
        <title><![CDATA[An In silico analysis on the phosphorylation dependent structural and thermal stability of thermophilic proteins]]></title>
        <pubdate>2026-05-06T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Sermarajan Arunachalam</author><author>Ramachandran Gnanasekaran</author>
        <description><![CDATA[In the present study the effect of phosphorylation on the structural stability and energy transfer in two structurally homologous thermophilic proteins, 1QMP and 1DZ3 were investigated. In 1QMP one of the residues (Asp55) phosphorylated while 1DZ3 this modification is not observed. This modification has provided an ideal model to explore the influence of phosphorylation on thermostability of the protein. Molecular dynamics (MD) simulations were performed to assess the structural stability and flexibility of both proteins following the analyses of root-mean-square deviation and root-mean-square fluctuation (RMSF). Subsequent, vibrational energy transfer calculations were followed to characterize pathways of intramolecular energy propagation and also to evaluate the effect of phosphorylation via residue level communication within the protein matrix. The key residues and interaction networks involved in energy transport were visualized through communication maps, provided insights into influence of phosphorylation on intramolecular energy flow and also on the overall structural stability. Furthermore, steered molecular dynamics simulation were carried out to reveal the unfolding mechanism and thermal resistance of the proteins under the influence of applied force. The results have revealed that the 1QMP possess higher structural rigidity, enhanced energy transport efficiency, and greater resistance to unfolding as compared to 1DZ3. Overall, phosphorylation at Asp55 strengthens vibrational energy transfer pathways and contributes to the enhanced thermostability of thermophilic proteins.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1827333</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1827333</link>
        <title><![CDATA[Phosphorus recovery from high-COD and strongly acidic wastewater by vivianite crystallization: feasibility and optimization of operating conditions]]></title>
        <pubdate>2026-05-04T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Kai Cui</author><author>Guangyu Xu</author><author>Fei Ma</author><author>Hong Zhang</author><author>Jiahao Cao</author><author>Yan Yi</author><author>Kun Guo</author>
        <description><![CDATA[Acidified oil wastewater contains high concentrations of phosphorus and organic pollutants, which not only pose environmental risks but also contain recoverable phosphorus resources. However, its complex matrix (high COD and acidic environment) poses great challenges to phosphorus recovery technologies. This study successfully developed a new phosphorus recovery strategy adapted to the wastewater characteristics and optimized key operating parameters using response surface methodology. Key parameters including pH, Fe:P molar ratio, reaction time and residence time were investigated, clarifying their regulatory roles in the complex wastewater system. Under the optimal process conditions (pH = 7.77, Fe:P molar ratio = 2.24, reaction time = 2.23 h, and hydraulic residence time = 4.16 h), the phosphorus recovery rate reached 93.54%, and the vivianite crystallization rate reached 91.39%. Furthermore, a process parameter prediction model (the verification results and the model prediction was less than 2.1%) was established to produce vivianite crystallization with large particle size (d50 = 113.4 μm) and uniform morphology, realizing synchronous wastewater treatment and phosphorus recovery. This study confirmed the feasibility and controllability of phosphorus recovery through vivianite crystallization in complex acidified oil wastewater matrices, providing a sustainable technical path for addressing the dual issues of phosphorus resource shortage and environmental pollution.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1807712</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1807712</link>
        <title><![CDATA[Lipidated peptides and the limits of chemical control]]></title>
        <pubdate>2026-05-04T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Cesar Augusto Roque-Borda</author><author>Anamika Sharma</author><author>Fernando Rogério Pavan</author><author>Beatriz G. de la Torre</author><author>Fernando Albericio</author>
        <description><![CDATA[Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritically as evidence of improved molecular design. This Perspective highlights that lipidation can reshape peptide behaviour by partially shifting functional control from sequence-encoded molecular recognition toward context-dependent effects in which membrane interactions, carrier binding, supramolecular assembly, and residence time play an increasingly important role. Under such design-dependent conditions, enhanced activity may primarily reflect delivery- and exposure-driven amplification rather than improved intrinsic efficacy. While MIC values and endpoint assays remain valuable benchmarks of activity, they are insufficient on their own to guide rational optimization of lipidated peptides, as they conflate intrinsic activity with lipid-driven distribution and time-dependent effects. Accordingly, this Perspective argues not against lipidation itself, but for reframing lipidation as a deliberately controllable interaction element rather than a generic potency modifier, thereby restoring mechanistic interpretability and design robustness in peptide chemical biology.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1814633</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1814633</link>
        <title><![CDATA[Underwater drag reduction via self-healing and robust air plastrons stabilized by candle soot-based coatings]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Muhammad Imran Jamil</author><author>Arshia Komal</author><author>Mehboob Hassan</author><author>Mazloom Shah</author><author>Waqar Ahmed</author><author>Hafiz Muhammad Ali</author><author>Numan Ahmed</author><author>Fazal Haq</author><author>Sahid Mehmood</author><author>Shahid Iqbal</author><author>Meznah M. Alanazi</author><author>Shaimaa A. M. Abdelmohsen</author>
        <description><![CDATA[In marine environments, the increased drag force on vehicles impedes their speed underwater, leading to high energy consumption and reduced vehicle efficiency. Superhydrophobic coatings have gained remarkable attention regarding drag reduction. Due to the collapse of the air plastron, the change from Cassie–Baxter to Wenzel state at high fluid impalement pressures, and various chemical conditions, these coatings lose their ability to reduce drag in cold marine settings. Candle soot nanoparticles are deposited into an elastic binder to create a strong, environmentally friendly porous superhydrophobic covering with healable plastron to solve these difficulties. The interconnected nano-pores of the soot particles retain the drag reduction performance by robustly maintaining the air plastron under water. The water droplets bouncing on elastic soot coating cause drag reduction by reducing their contact time. The soot-coated copper ball enfolds the gas cavity volume 14.83 times greater than that of the bare ball while impacting water. The near-zero drag coefficient values of the soot-coated copper sphere confirm its efficient drag reduction performance. In Taylor-Couette flow, the soot-coated rotor showed a 60% drag reduction as compared to the bare rotor. The rheological experiments showed a 15.26% reduction in the apparent viscosity of glycerol and a 13.86% shear stress reduction on soot coated surface at −10 °C. The soot-coated boat covered 31 cm more distance at high speed than the uncoated boat. The plastron of candle soot coating showed stability under lake water, pond waters, super-cold water, liquid nitrogen, acidic and basic media, artificial seawater, different organic solvents, and sand abrasion. Moreover, a soot-coated aluminium plate floated on the surface of water while bearing a load. The durability, passive plastron stability, and self-cleaning of candle soot superhydrophobic coating have the potential for efficient drag reduction and are suitable for large-scale applications even in arctic environments in order to improve the fuel efficiency and substantial energy savings.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1852717</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1852717</link>
        <title><![CDATA[Correction: Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Correction</category>
        <author>Gbolahan O. Oduselu</author><author>Rhoda O. Olatuyi</author><author>Omowunmi O. Fatoki</author><author>Damilola S. Bodun</author><author>Promise E. Sunday</author><author>Wellington Oyibo</author><author>Olayinka O. Ajani</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1861325</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1861325</link>
        <title><![CDATA[Editorial: New trends in green chemistry: sustainable and alternative strategies for the extraction of high-value compounds from agri-food matrices and residues]]></title>
        <pubdate>2026-04-30T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Francesca Annunziata</author><author>Gigliola Borgonovo</author><author>Patricia Rijo</author><author>Andrea Pinto</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1790752</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1790752</link>
        <title><![CDATA[Diol-enhanced natural deep eutectic solvents for efficient poplar pretreatment]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Chaehwi Yoon</author><author>Jiae Ryu</author><author>Soyeon Jeong</author><author>Aymerick Eudes</author><author>Kwang Ho Kim</author><author>Chang Geun Yoo</author>
        <description><![CDATA[Natural deep eutectic solvents (NDESs) are promising biomass pretreatment media, but their industrial application is often hindered by high viscosity. To address this limitation, diol-enhanced ternary DESs (TDESs) were prepared by incorporating 1,4-butanediol (1,4-BDO) or ethylene glycol (EG) into a choline chloride (ChCl) and 3,4-dihydroxybenzoic acid (DHBA) system. The applied TDESs maintained a liquid state at room temperature and had significantly reduced viscosity compared to the binary DES (BDES). In addition, the applied diols increased lignin solubility and suppressed lignin condensation by intercepting reactive carbocation intermediates. As a result, the recovered lignins from diol-induced TDES pretreatments showed better preservation of β-O-4 linkages and reduced condensation, improving their potential for downstream valorization. The diol-assisted DES systems showed a synergistic effect from the reduced viscosity, enhanced lignin solubility, and suppression of unwanted condensation, resulting in more effective biomass pretreatment performance, including the enhanced delignification and higher enzymatic digestibility compared to BDES. The 1,4-BDO-enhanced DES was also successfully applied to DHBA-enriched transgenic poplar, highlighting its potential for the processing of engineered biomass feedstocks.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1800775</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1800775</link>
        <title><![CDATA[Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mohamed F. Zayed</author><author>Yosra Muhammad</author><author>Aymen A. Alqurain</author><author>Mohammed A. A. Banafa</author><author>Abdelsattar M. Omar</author>
        <description><![CDATA[IntroductionFive new quinazoline-sulfonamide hybrids 4a (MZ-13), 4b (MZ-20), 4c (MZ-25), 4d (MZ-26), and 6a (MZ-29) were designed, synthesized, and investigated for their in vitro and in vivo antidiabetic activities.MethodsThe in vivo screening was conducted in a mouse model of type II diabetes induced by streptozotocin (STZ), using glibenclamide as the positive control. The in vitro model was performed by measuring the activity of these compounds against the PPARγ enzyme. Furthermore, the total antioxidant capacity (TAC) was measured for these compounds to assess their ability to neutralize a wide range of free radicals. A physicochemical study was conducted to demonstrate the drugability of these compounds. Additionally, the in silico ADMET and toxicity studies illustrated good pharmacokinetic properties and a low toxicity profile. Likewise, a comprehensive molecular modeling study was performed to examine the binding modes of the new compounds.ResultsCompound MZ-29 showed 27.1% reduction in blood glucose (BG) levels, and the standard glibenclamide showed 17.2% reduction in BG. The in vitro assay of the compounds MZ-13 and MZ-29 demonstrated superior or comparable activity to the reference glibenclamide.DiscussionThe study identified MZ-29 and MZ-26 as the most promising candidates in the series. These two compounds achieved docking scores and binding orientations closely mimicking the native ligand.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1800761</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1800761</link>
        <title><![CDATA[Eco-friendly synthesis of an antimicrobial polymer (1,4-bis(methacryloyl)piperazine) via maghnite catalysis: in vitro activity and in silico drug-likeness]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Samira Derkaoui</author><author>Farouk Boudou</author><author>Ahcene Keziz</author><author>Alaeddine Berkane</author><author>Huda Alsaeedi</author><author>David Cornu</author><author>Mikhael Bechelany</author><author>Ahmed Barhoum</author>
        <description><![CDATA[BackgroundPoly (1,4-bis(methacryloyl)piperazine) (poly (NBMP)) is a piperazine-based polymer with potential biomedical applications. Green clay catalysts, maghnite-H+ and maghnite-Na+; offer an eco-friendly approach for monomer (NBMP) and polymer (poly (NBMP)) synthesis with improved yields and low toxicity.AimTo synthesize poly (NBMP) via green catalysis, evaluate its structural properties, and investigate its antimicrobial potential along with drug-likeness and molecular interaction profiles of its monomer.MethodThe monomer and polymer were synthesized using varying amounts of maghnite-H+ and maghnite-Na+ at controlled temperatures. Structural characterization was performed using FTIR, 1H and 13C NMR, SEM, and DSC. Antibacterial activity was tested against Gram-positive (S. aureus, L. monocytogenes) and Gram-negative bacteria (E. coli, P. aeruginosa, K. pneumoniae). Drug-likeness, toxicity predictions, molecular docking, and molecular dynamics (MD) simulations were conducted to assess binding affinities and complex stability of NBMP with the target bacterial proteins.ResultsMonomer yield increased from 40% to 72% with 0–10 wt% maghnite-H+, while polymer yield rose from 5% to 70% using 0–15 wt% catalyst. Poly (NBMP) exhibited significant antibacterial activity, with inhibition zones of 32 μg/mL against S. aureus and 16 μg/mL against E. coli. Docking studies revealed moderate binding to K. pneumoniae FabG (PDB ID: 6T77, −6.1 kcal/mol). MD simulations confirmed stable complexes with RMSD values of 0.43 nm for E. coli DNA gyrase (PDB ID: 1KZN) and 0.19 nm for K. pneumoniae FabG, along with low RMSF and compact radius of gyration (0.04–0.07 nm).DiscussionThe findings demonstrate that NBMP forms stable interactions with bacterial proteins, supporting its broad-spectrum antimicrobial activity. The eco-friendly synthesis, favorable drug-likeness, and structural stability highlight NBMP as a promising candidate for future biomedical applications. Further in vitro and in vivo studies are recommended to validate its therapeutic potential.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1799700</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1799700</link>
        <title><![CDATA[Facile synthesis of rGO/NiWO4 hybrid electrocatalyst for enhanced oxygen evolution reaction in alkaline medium]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>D. J. Patil</author><author>D. B. Malavekar</author><author>V. C. Lokhande</author><author>J. H. Kim</author><author>C. D. Lokhande</author>
        <description><![CDATA[Growing energy consumption and concerns regarding the effects of global warming are driving development of greener energy alternatives. Green hydrogen production and consumption are essential in modern energy conversion and storage. The progression of water splitting technologies for sustainable hydrogen production relies on the development of efficient and cost-effective electrocatalysts for the oxygen evolution reaction (OER). Here, we present nickel tungstate (NiWO4) and reduced graphene oxide composited nickel tungstate (rGO/NiWO4) synthesis via an easily processable successive ionic layer adsorption and reaction (SILAR) method, and its OER performance in an alkaline electrolyte. While NiWO4 exhibited poor OER performance and stability, the incorporation of rGO significantly stabilized the composite electrode and extended its stability. The introduction of rGO reduced the charge transfer resistance and enhanced the surface area of the composite electrode compared to NiWO4. As a result, rGO/NiWO4 electrocatalyst exhibited a lower overpotential of 210 ± 10 mV at 50 mA cm−2 and a Tafel slope of 60 ± 3 mV dec−1, compared to NiWO4 (260 ± 13 mV, 60 ± 3 mV dec−1), showing enhanced catalytic performance. Additionally, the composite electrode demonstrated long term stability, over 50 h of continuous operation. These findings demonstrate rGO/NiWO4 as a promising OER electrocatalyst for efficient water splitting.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1812827</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1812827</link>
        <title><![CDATA[Bulky PP1 analogs exert cellular effects independently from analog-sensitive kinase inhibition]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Coralie Gicquel</author><author>Sabine Genicot</author><author>Arnaud Comte</author><author>Pierre Colas</author>
        <description><![CDATA[To circumvent the general lack of selectivity of protein kinase inhibitors, a chemical genetics approach has been developed to allow the selective targeting of engineered kinases by bulky ATP analogs, most of which derived from the pyrazolo[3,4-d]pyrimidine 1 (PP1) inhibitor. Although designed to selectively inhibit so-called analog-sensitive (AS) kinases presenting enlarged active sites, bulky PP1 analogs were shown to inhibit a number of wild-type protein kinases in vitro. Here, we examine the effects of 5 bulky PP1 analogs on the migration, invasive potential, proliferation, cell cycle, viability and differentiation of non-tumoral and tumoral cell lines that do not express an AS kinase. We show that the three inhibitors that have been employed the most so far (1NA-, 1NM-, 3MB-PP1) produce conspicuous effects on these cellular processes, sometimes at lower concentrations than those often used in AS kinase studies. Our work calls for caution when interpreting some cellular effects obtained with PP1 analogs used at concentrations ≥5 µM or even 2 µM for the least specific of them. Whenever possible, it advocates the use of lower concentrations of 3IB- or 3MSB-PP1 that produce less non-specific effects, as predicted from previously published in vitro data.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1834317</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1834317</link>
        <title><![CDATA[CS-DTA: a language model-driven framework for robust drug-target affinity prediction under strict cold-start scenarios]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Zhaokun Jiang</author><author>Heying Dai</author><author>Yongxv Chen</author><author>Baixue Qiao</author><author>Shanwen Sun</author>
        <description><![CDATA[IntroductionAccurate prediction of drug-target affinity is important for computational drug discovery, yet many deep learning models show limited robustness when applied to unseen compounds or previously uncharacterized proteins.MethodsWe developed CS-DTA, a modular DTA prediction framework that integrates large language models (LLMs) for compound and protein representation learning with a cross-modal interaction module. By leveraging the strong transferability of LLM-based encoders, the model can capture rich semantic and structural patterns from both molecular sequences and protein sequences. The cross-modal attention mechanism further enhances prediction by explicitly modeling fine-grained interactions between compound and protein representations, enabling more effective fusion of complementary biochemical information.ResultsCS-DTA achieved state-of-the-art predictive performance across warm-start and strict cold-start scenarios. Ablation analyses showed that the dual-encoder representation backbone was the primary source of predictive robustness. Interpretability analyses highlighted compact ligand substructures and localized protein regions with plausible relevance to binding. In downstream screening, CS-DTA prioritized known target-specific interactions, and selected predictions were supported by molecular docking. The non-kinase validation provided preliminary evidence of partial transferability beyond the kinase-focused benchmark setting.DiscussionThe above results demonstrate that CS-DTA offers a robust and interpretable approach for DTA prediction. By integrating LLM-based encoding with a modular interaction architecture, the framework enhances generalization to previously unseen compounds and proteins while maintaining biologically meaningful interpretability. This combination makes CS-DTA a promising framework for virtual screening and early-stage drug discovery.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1780357</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1780357</link>
        <title><![CDATA[Strategic applications of heterocyclic compounds in pharmaceutical innovation: a business perspective]]></title>
        <pubdate>2026-04-28T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Yan Dong</author><author>Jindong Dai</author><author>Yuerong Zou</author><author>Kanagaraj Rajalakshmi</author><author>Natarajan Kiruthiga</author><author>P. Balaji</author><author>Dongwei Zhu</author>
        <description><![CDATA[The heterocyclic compound is one of the finest spanned backbones for developing most innovative agents in the pharmaceutical industry. These adaptable molecules have played an important role in the discovery of therapeutic agents of a wide range, including antibiotics, anticancer drugs and antivirals. The role of heterocyclic chemistry in pharmaceutical innovation is thus one that extends beyond mere structural complexity but contributes significantly to improved therapeutic index, and in doing so stimulates economic activity in the field. The medicinal significance of heterocycles, their role in drug discovery, and their commercial prospects are discussed in the Research article. It explores types of heterocyclic compounds, its historical importance, influence on the world health and market trends delivering its industrial usage. Synthetic challenges, regulatory hurdles, and sustainability concerns are discussed in tandem with future opportunities that may arise from advancements in green synthesis and artificial intelligence (AI)-driven drug discovery. This study emphasizes the transformative potential of heterocyclic compounds in modern medicine by connecting their scientific advancements to business strategies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1855585</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1855585</link>
        <title><![CDATA[Retraction: Green synthesis, characterizations of silver nanoparticles using sumac (Rhus coriaria L.) plant extract and their antimicrobial and DNA damage protective effects]]></title>
        <pubdate>2026-04-27T00:00:00Z</pubdate>
        <category>Retraction</category>
        
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1789689</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1789689</link>
        <title><![CDATA[Synergetic effects of silicon nanoparticles and multi-walled carbon nanotubes on the structural and dielectric properties of polystyrene-based nanocomposites]]></title>
        <pubdate>2026-04-24T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>María Fernanda Cuenca-Lozano</author><author>Habiba Aslan Shirinova</author><author>Lala Rasim Gahramanli</author><author>Flora Vidadi Hajiyeva</author><author>Sevinj Garib Nuriyeva</author><author>Aynura Hidayat Karimova</author><author>Eldar Kochari Gasimov</author><author>Fuad Huseynali Rzayev</author><author>Aysel Ilgar Masimova</author><author>Narmin Yashar Suleymanova</author><author>Raida Zabit Ibaeva</author><author>Cristian Vacacela Gomez</author>
        <description><![CDATA[In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon particles (Si) and multi-walled carbon nanotubes (MWCNTs) were prepared, their structural, dielectric, and mechanical properties were investigated. X-ray diffraction (XRD) analysis confirmed the polycrystalline nature of Si nanoparticles and the preservation of the MWCNTs’graphitic (002) structure. Atomic Force Microscope (AFM) analysis confirmed that the addition of hybrid fillers leads to changes in the surface morphology. It was determined that the root mean square (RMS) surface roughness decreased from approximately 85 nm for pure MWCNTs to about 30 nm for the HIPS + Si + MWCNT nanocomposite. Dielectric measurements showed that the HIPS+1.5 wt.%Si+1.5 wt.%MWCNT nanocomposite exhibited the highest dielectric response. The dielectric constant increased by approximately 3.5 times at 1 kHz compared to neat HIPS. A relaxation maximum observed at 125 Hz and was corresponding to an effective relaxation time of τ = 1.27 m. At 200 kHz, the AC conductivity was calculated as σ ≈ 10–8 S/cm, consistent with near-percolation behavior. Mechanical testing revealed that tensile strength increased from 14.06 MPa to 17.49 MPa with hybrid filler incorporation, while relative elongation decreased from 82% to 17.88%, indicating the typical stiffness–ductility trade-off. The results demonstrate that hybrid Si/MWCNT fillers induce synergistic effect on dielectric and mechanical performance in HIPS-based nanocomposites.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1847404</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1847404</link>
        <title><![CDATA[Editorial: Emerging trends in biosensors: bridging chemistry and practical applications]]></title>
        <pubdate>2026-04-23T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Rui Wang</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1632736</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1632736</link>
        <title><![CDATA[Sustainable synthesis of quinazolinones: exploring multicomponent reactions with a novel magnetic palladium catalyst]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Xiaotong Liang</author><author>Ziqi Yang</author><author>Bo Li</author>
        <description><![CDATA[This study introduces a sustainable and efficient method for synthesizing quinazolinones, a class of heterocyclic compounds with significant pharmaceutical applications, via a multicomponent reaction (MCR) strategy. The process employs a novel magnetically recoverable palladium catalyst, enabling the coupling of aryl or heteroaryl iodides with a carbonyl source and 2-aminobenzamide in an eco-friendly PEG/water solvent system, facilitated by potassium carbonate as a base. The magnetic Pd catalyst exhibits robust catalytic activity, achieving high product yields (82%–98%) across diverse substrates, including electron-rich and electron-deficient aryl/heteroaryl iodides, underscoring its broad applicability. The catalyst is synthesized and characterized through various techniques, including FT-IR, BET, TGA, EDX, VSM, SEM, TEM, and XRD, which affirm its uniformity and stability. Key advantages of this protocol include exceptional atom economy, elimination of toxic solvents, and mild reaction conditions. The catalyst’s magnetic properties allow effortless recovery via external magnetization, retaining >89% activity over five consecutive cycles, enhancing cost-effectiveness and sustainability. The methodology advances sustainable synthetic practices and holds promise for scalable applications in medicinal and industrial chemistry. This work highlights the transformative potential of magnetic nanocatalysts in developing eco-conscious routes to biologically relevant heterocycles.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1811060</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1811060</link>
        <title><![CDATA[Na+/K+-ATPase, cardiac glycosides, and tumor immunity]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Yulin Ren</author><author>Jianhua Yu</author><author>Xiaolin Cheng</author><author>A. Douglas Kinghorn</author>
        <description><![CDATA[Tumor immunity arises from the coordinated action of innate and adaptive immune systems but is hindered by immune escape within the immunosuppressive tumor microenvironment (TME), for which ion channels and ion pumps have proved to be important. These proteins regulate a wide range of cellular processes to influence cancer progression and immune cell functions, of which ion channels maintain intracellular ion concentrations, cytosolic pH, and cell volume and functions and are essential for cancer development and immune regulation. Ion pumps correlate closely with ion channels and show an important effect on tumor immunity. Of these, H+-ATPases, especially vacuolar H+-ATPase (V-ATPase), play critical roles in cancer progression, metastasis, and immune evasion, while Na+/K+-ATPase (NKA) interacts with ion channels and H+-ATPase and hence contributes to antitumor immune responses. Thus, several cardiac glycoside inhibitors have been reported to exert potent antitumor and immunomodulatory activities. In the present perspective article, the interconnections among NKA, ion channels, H+-ATPases, and immune responses are addressed, with the potential activities of cardiac glycosides on tumor immunity discussed.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1794622</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1794622</link>
        <title><![CDATA[Precision intervention based on infection site: strategies and advances of magnetic nanomaterials in bacterial therapy]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Guangxin Zhang</author><author>Peiyi Liang</author><author>Xiying Fu</author><author>Yicun Wang</author>
        <description><![CDATA[Bacterial infections, especially those involving drug-resistant pathogens and biofilms, pose a severe global health threat. Conventional antibiotic therapies are limited by poor penetration, low specificity, and bacterial resistance mechanisms. Magnetic nanoparticles (MNPs) offer a promising alternative by combining magnetically guided targeting, magnetothermal/photothermal effects, multifunctional drug delivery, and imaging capabilities. Their antibacterial efficacy depends critically on the anatomical and pathological features of the infection site. For skin and superficial infections, near-infrared (NIR) light, particularly in the second biological window (NIR-II), enables synergistic photothermal/photodynamic/chemodynamic therapies. For deep soft tissue and bone infections, alternating magnetic fields (AMF) provide deep-penetrating magnetothermal activation or targeted enrichment, often combined with image-guided intervention. For cavity organ and implant-related infections, surface functionalization, local drug delivery, and endoscopic energy application allow precise interfacial intervention. This review systematically discusses MNP-based strategies tailored to different infection sites, integrating advances in material design, synergistic mechanisms, and preclinical progress. It also addresses challenges in multifunctional integration, biosafety, and clinical translation, and outlines future directions toward intelligent, theranostic, and synergistic antibacterial platforms.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1814119</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1814119</link>
        <title><![CDATA[Development of a novel series of thiazole-based compounds with enhanced antiproliferative properties as tubulin polymerization inhibitors]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Lamya H. Al-Wahaibi</author><author>Ali M. Elshamsy</author><author>Taha F. S. Ali</author><author>Bahaa G. M. Youssif</author><author>Stefan Bräse</author><author>Mohamed Abdel-Aziz</author><author>Nawal A. El-Koussi</author>
        <description><![CDATA[IntroductionIn cancer therapy, inhibiting tubulin polymerization is a key approach for modifying microtubule dynamics required for cell survival and proliferation. Microtubule destabilizing agents (MDAs), also known as tubulin polymerization inhibitors, prevent tubulin heterodimers from forming microtubules, resulting in catastrophic cellular collapse.MethodsA novel series of thiazole-based compounds 8a-o was developed to inhibit tubulin polymerization and assess for its antiproliferative efficacy against the NCI 60 cell line. The structures of the newly synthesized compounds were confirmed using 1H NMR, 13C NMR, and elemental microanalyses. All 15 compounds (8a-o) were assessed for antiproliferative action at a single dosage (10 μM) and analyzed against the comprehensive 60-cell panel at five concentrations (0.01, 0.1, 1, 10, and 100 μM).Results and DiscussionThe results from the one-dose and five-dose studies demonstrate that 8b, 8c, 8d, 8m, and 8o are the most prominent antiproliferative agents, exhibiting the most favourable low-micromolar GI50 values across various cell lines, frequently advancing to low-micromolar TGI, and, in numerous sensitive cell lines, achieving LC50 values within the single-digit micromolar range. Compounds 8b, 8d and 8m showed significant anti-tubulin activity, with IC50 values ranging from 3.86 to 7.19 μM, compared to the reference CA-4 (IC50 = 2.40 μM). In the MCF-7 breast cancer cell line, compound 8m drove a significant accumulation of cells in the G2/M phase, increasing from 13.74% to 45.35%. G2/M arrest is frequently associated with DNA damage or the inhibition of microtubule dynamics, which aligns with Western blot results demonstrating a decrease in tubulin (50 kDa) expression following treatment with 8m. Apoptotic and necrotic experiments indicate that 8m stimulates a defined programmed cell death pathway rather than inducing non-specific toxic necrosis. Molecular docking corroborated their binding at the colchicine site, while in silico ADMET profiling indicated a promising drug-like profile for compound 8m.]]></description>
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