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        <title>Frontiers in Chemistry | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/chemistry</link>
        <description>RSS Feed for Frontiers in Chemistry | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-13T05:36:55.589+00:00</pubDate>
        <ttl>60</ttl>
        <item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1840199</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1840199</link>
        <title><![CDATA[Electrolyte design and interface engineering for high-voltage solid-state lithium batteries]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Xianzheng Liu</author><author>Nashrah Hani Jamadon</author><author>Yueyue Yu</author><author>Liancheng Zheng</author><author>Rongji Tang</author>
        <description><![CDATA[Solid-state lithium batteries (SSLBs) have attracted extensive attention as next-generation energy-storage systems because they offer improved safety and the possibility of coupling lithium metal anodes with high-energy cathodes. Among the many development directions of SSLBs, high-voltage systems are particularly important because they provide a direct pathway toward higher energy density. However, under high-voltage operation, typically above approximately 4.3 V versus Li+/Li but strongly dependent on cathode chemistry and state of charge, both the solid electrolyte and the electrode/electrolyte interface are subjected to severe electrochemical and structural challenges. Electrolyte oxidation, cathode-induced interfacial decomposition, space-charge effects, mechanical contact loss, and manufacturing difficulties jointly limit the practical performance of high-voltage SSLBs. This review systematically summarizes recent advances in electrolyte design for high-voltage SSLBs, covering inorganic solid electrolytes, polymer electrolytes, organic–inorganic composite electrolytes, gel polymer electrolytes, and quasi-solid-state electrolytes. In addition, the critical role of interface engineering is discussed with emphasis on cathode-side stabilization strategies, interphase regulation, and coating design. Finally, the major challenges and future research directions for high-voltage SSLBs are presented. The development of high-voltage SSLBs requires synergistic optimization of electrolyte chemistry, interfacial stability, and scalable processing strategies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1782485</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1782485</link>
        <title><![CDATA[Integrative characterization of Huachansu against hepatocellular carcinoma: chemical profiling, Network pharmacology, and in vivo evidence of apoptosis and gut microbiota remodeling]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Jinghui Zhang</author><author>Yang Chen</author><author>Zhuoling An</author><author>Hengyuan Yu</author>
        <description><![CDATA[BackgroundHepatocellular carcinoma (HCC) remains a major global health burden, and traditional Chinese medicine (TCM) offers complementary therapeutic advantages. Although Huachansu (HCS), a clinically used TCM preparation, contains key bioactive components, including bufalin (BFL) and cinobufotalin (CBF), its antitumor mechanisms remain unclear.MethodsLC–MS profiling was performed to characterize the chemical constituents of HCS. Network pharmacology analysis was conducted by integrating predicted compound targets with HCC-associated genes to identify overlapping targets and enriched biological pathways. Subsequently, molecular docking was used to evaluate binding interactions between active compounds and hub proteins. Finally, the antitumor effects of BFL and CBF were validated in vivo, and gut microbiota alterations were assessed using 16S rRNA sequencing.ResultsLC–MS profiling identified 17 HCS constituents, predominantly bufadienolides, establishing a chemical basis for mechanistic analyses. Network pharmacology analysis defined 142 overlapping targets enriched in apoptosis-related processes and cancer pathways. Molecular docking supported stable binding between bioactive compounds and key hub proteins, including STAT3, EGFR, AKT1, and PARP1, suggesting apoptosis-centered regulation. Guided by these in silico findings, in vivo experiments demonstrated that BFL and CBF reduced tumor burden and proliferation, as evidenced by hematoxylin and eosin staining and Ki-67 immunohistochemistry. Enhanced apoptosis was confirmed by TUNEL staining and Bax/Bcl-2 expression profiling, with more pronounced effects under combined treatment. Moreover, 16S rRNA sequencing revealed gut microbiota remodeling following BFL, CBF, and their combination treatments.ConclusionThese findings clarify the apoptosis-associated anti-HCC mechanism of HCS and provide mechanistic insights supporting development of TCM-based anticancer agents.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1809343</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1809343</link>
        <title><![CDATA[Porosity in electrochemical energy storage materials for superior performance gaining: insight into property performance and looking ahead]]></title>
        <pubdate>2026-05-13T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Pan Shulin</author><author>Walid Tahri</author><author>Amani Khaskhoussi</author><author>Mazen Alshaaer</author>
        <description><![CDATA[The use of renewable energy, electric vehicles, and high-density compact devices requires the power density, long-term stability, and long cycle life of the electrochemical energy storage (ESS) systems. Ion transport, charge storage and mechanical stability of the electrode can be improved with high specific surface area and porous electrodes with well-designed pore structures and high accessibility of electrolytes to the electrodes. The present work critically outlines the current trends in the porous electrode materials, which are porous carbons, inorganic porous structures and coordinated hybrid/composite structures. The relationships between structure, property, and performance that dictate electrochemical behavior and design approaches such as hierarchical porosity, surface functionalization and heterostructure hybridization are pointed out as having a contribution to improving capacitance, energy density and cycling stability. The primary challenges in the manner, in which such materials evolved in the laboratory can be transferred to the practice in the real world, including scaling up to mass production, the volumetric energy density, and the stability of electrodes on the actual cycling, are also stated. Efforts in the recent past have suggested that the objective of pore engineering should be oriented towards equilibrium between the surface area, mechanical stability, and volumetric functionality. The devices of the future EES will need a blend of rational material design and manufacturability approaches to help close the gap between new and innovative porous electrode concepts and commercial energy storage technologies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1799409</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1799409</link>
        <title><![CDATA[Engineering the surface chemistry of silicon nanocrystals for efficient Ag-Si hybrid photocatalysts toward CO2 reduction]]></title>
        <pubdate>2026-05-12T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Huai Chen</author><author>Xuebiao Deng</author><author>Meiqi Lin</author><author>Lei Liang</author><author>Tingting Chen</author><author>Jiale Si</author><author>Yangyang Xiong</author><author>Zhenyu Yang</author><author>Linwei Yu</author>
        <description><![CDATA[Plasmonic nanoparticles (NPs) enable exceptional light harvesting via localized surface plasmon resonances (LSPR), yet their photocatalytic utility is limited by ultrafast charge recombination and surface contamination from synthesis. Here, we overcome these challenges by applying the surface chemistry of silicon nanocrystals (SiNCs) to synthesize hybrid nanostructures of uncoated silver nanoparticles (AgNPs). The alkyl-passivated SiNC surface acts as a reductive template, guiding the in-situ formation of clean, interfacially coupled AgNPs while protecting the SiNC core from oxidation. This tailored architecture leverages a synegiestic mechanism to enhance AgNP plasmon resonance, drive efficient hot-electron transfer and improve charge carrier separation. The resulting Ag@SiNC hybrid achieves improved CO2 reduction performance, with a CO yield of 1,552 μmol/g and near 100% selectivity under visible light irradiation. This work establishes surface-engineered SiNCs as a versatile platform for designing high-performance plasmonic–semiconductor photocatalysts.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1841478</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1841478</link>
        <title><![CDATA[Editorial: Advanced functional materials, structures, and devices for advancing human healthcare applications]]></title>
        <pubdate>2026-05-12T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Feiran Li</author><author>Tianlong Li</author><author>Zhuang Hao</author><author>Dalei Jing</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1806549</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1806549</link>
        <title><![CDATA[Graph-based deep learning for drug-drug interaction prediction: a systematic review]]></title>
        <pubdate>2026-05-11T00:00:00Z</pubdate>
        <category>Mini Review</category>
        <author>Xiaoqing Liu</author><author>Xue Yu</author><author>Qi Dai</author>
        <description><![CDATA[Identifying potential drug–drug interactions (DDIs) is crucial for drug development and therapeutic safety, motivating increasing efforts in computational DDI prediction. Although several surveys have summarized recent advances, a systematic review that explicitly organizes existing studies from the perspective of graph-based deep learning paradigms is still lacking. In this work, we present a comprehensive review of graph-based methods for DDI prediction, with a particular focus on three representative technical routes: graph convolutional networks (GCNs), graph attention networks (GATs), and graph contrastive learning (GCL). We review and categorize representative DDI prediction models according to these three paradigms, highlighting their modeling strategies, advantages, and limitations in capturing molecular structures, heterogeneous interactions, and robust representations. We then discuss key challenges and future research directions, emphasizing multi-modal data integration and model interpretability. This review aims to provide a structured overview of the current landscape and to serve as a practical reference for the development of more accurate, robust, and interpretable DDI prediction models.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1829431</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1829431</link>
        <title><![CDATA[Advanced materials for high-performance electrochemical water-splitting: a review of recent breakthroughs, and future prospects]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Momna Qayyum</author><author>Sammia Shahid</author><author>Sana Mansoor</author><author>Urooj Fatima</author><author>Mohsin Javed</author><author>Salah Knani</author><author>Reem Alreshidi</author><author>Shahid Iqbal</author>
        <description><![CDATA[The sluggish HER/OER kinetics and the lack of dependable, highly efficient electrocatalysts limit the large-scale use of electrochemical water splitting, despite its potential as a sustainable hydrogen generating technique. This review presents comprehensive and mechanistically informed evaluation of the advanced electrocatalysts with particular emphasis on non-noble metal-based systems, including nanostructure surfaces, layer double hydroxides (LDH), metal-organic frameworks (MOFs), high-entropy materials (HEMs), perovskites, graphene-based materials, and covalent-organic frameworks (COFs). This review provides a unified framework for structure, property, and performance by correlating the strategies for the catalysts design, such the heteroatom doping, defect engineering, and the hybrid interface construction, with that of the key performance metrics including the current density, stability, cell voltage, and overpotential. Additionally, the influence of the operating conditions is also considered to offer more realistic perspective on the performance of the catalysts across the different electrochemical environments. Through the critical evaluation of the recent advancements, this review identifies key trends governing the catalytic behavior including the role of the active site engineering, interfacial effects, and the modulation of the electronic structure. This review outlines the actionable strategies which are aimed at bridging the gap between the laboratory-scale studies and the industrial water splitting, thus offering a rational framework for the development of the next-generation electrocatalysts for sustainable hydrogen production.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1834067</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1834067</link>
        <title><![CDATA[Data-driven theoretical characterization of β-decay spectra in radioisotope energy materials via artificial fish swarm optimized adaptive kernel density estimation]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Yichen Ma</author><author>Changlong Cai</author><author>Huachen Liu</author><author>Hongmei Zong</author><author>Xuerui Wang</author><author>Chenxing Wu</author>
        <description><![CDATA[IntroductionAccurate modeling of beta-decay energy spectra is essential for theoretical analysis and performance optimization in radioisotope energy conversion. Conventional parameterization methods may introduce fitting bias, while fixed-bandwidth KDE lacks local adaptability for asymmetric, multi-peak and long-tailed spectral distributions.MethodsThis study developed an Artificial Fish Swarm Algorithm-Adaptive Kernel Density Estimation (AFSA-AKDE) framework. After spectral data preprocessing, RMSE was used as the fitness function, the bandwidth was reformulated as an adaptive coefficient-controlled structure, and AFSA was used to optimize key parameters through foraging, swarming and following behaviors.ResultsThe method was validated using Ni-63, S-35 and C-14 samples with different thicknesses. For a 2 um Ni-63 sample, AFSA-AKDE achieved MAE = 0.0116%, RMSE = 0.0156% and R2 = 0.9998792. For a 0.2 um C-14 sample, it achieved MAE = 0.0158%, RMSE = 0.0243% and R2 = 0.996687.DiscussionCompared with fixed-bandwidth KDE, normal distribution models and recent adaptive KDE variants, AFSA-AKDE provides improved accuracy, stability and local adaptability for reconstructing complex beta-decay energy distributions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1845768</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1845768</link>
        <title><![CDATA[Cerium-based nanozymes for chemodynamic therapy: tumor microenvironment-responsive mechanisms and applications]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Yuan Lu</author><author>Yamin Wu</author><author>Ke Wen</author><author>Zhenzhen Wei</author><author>Lu Huang</author><author>Mengyao Zhang</author><author>Xuetao Huang</author><author>Qian Liu</author>
        <description><![CDATA[Cerium-based nanozymes (CeNZs) are a class of nanomaterials possessing enzyme-like catalytic activities. Their unique Ce3+/Ce4+ redox pair and multi-enzyme mimicking activities make them highly advantageous for tumor chemodynamic therapy (CDT). This review systematically summarizes recent research progress in the application of CeNZs for tumor CDT. It focuses on their multi-enzyme catalytic mechanisms and the intelligent regulation of their catalytic behavior by the tumor microenvironment. Furthermore, it elaborates on various CeNZ-based CDT strategies, including single-modality CDT, self-supplying CDT, and combination therapies integrated with photothermal therapy, photodynamic therapy, sonodynamic therapy, and chemotherapy. Finally, the challenges and future directions for the clinical translation of CeNZs are discussed, focusing on precise design, biosafety, and efficacy evaluation. As high-performance and tunable nanocatalytic platforms, CeNZs hold broad prospects for developing efficient and low-toxicity tumor treatment strategies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1790990</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1790990</link>
        <title><![CDATA[Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Sachin Baravkar</author><author>Varsha J. Thombare</author><author>Yuezhou Wu</author><author>Nitin A. Patil</author>
        <description><![CDATA[Antimicrobial depsipeptides and cyclodepsipeptides represent a structurally diverse class of natural products that have gained renewed attention as both antibacterial agents and molecular tools to interrogate bacterial physiology. Characterized by the incorporation of ester linkages within macrocyclic peptide frameworks, these molecules exhibit unique conformational properties that underpin distinct modes of action including lipid II recognition, membrane perturbation, and enzyme modulation. This review summarizes advances in discovery, chemical synthesis, and structure activity relationship studies across major depsipeptide families, highlighting how precise chemical features such as macrocycle topology, stereochemical configuration, hydroxylation patterns, and lipidation dictate biological function. By integrating mechanistic insights from chemical biology, microbiology, and medicinal chemistry, we illustrate how cyclodepsipeptides serve as privileged scaffolds for probing bacterial cell envelope organization and essential biosynthetic pathways. In the context of escalating antimicrobial resistance and limited innovation in small molecule antibiotics, these macrocyclic peptides offer valuable opportunities for mechanism driven probe development and therapeutic translation. Collectively, this article provides a unified framework linking molecular structure to antibacterial activity and aims to guide the rational design of next-generation peptide-based antibiotics.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1777981</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1777981</link>
        <title><![CDATA[Synthesis, structure–activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors]]></title>
        <pubdate>2026-05-08T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ling-Jie Gao</author><author>Demian Kalebic</author><author>Chieh Wen Lo</author><author>Aakriti Gangwal</author><author>Do Hoang Nhu Tran</author><author>Jef Rozenski</author><author>Dominique Schols</author><author>Mathy Froeyen</author><author>Wim Dehaen</author><author>Shirit Einav</author><author>Steven De Jonghe</author>
        <description><![CDATA[Introduction3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines have previously been shown to be potent inhibitors of the lipid kinase FYVE finger-containing phosphoinositide kinase (PIKfyve), displaying broad-spectrum antiviral activity.MethodsTo further study their structure–activity relationship (SAR), an efficient synthesis toward 3- bromo-5-chloro-isothiazolo[4,3-b]pyridine was established. It allowed to introduce structural modifications at positions 3 and 5 by palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions.Results and discussionIt led to the generation of a focused library of 3,5-disubstituted isothiazolo[4,3-b]pyridines. Several derivatives exhibited potent PIKfyve inhibition (in the low nM range) in a biochemical assay and antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (in the low μM range). To gain an insight in their binding mode, molecular modeling was applied, indicating that these 3,5- disubstituted isothiazolo[4,3-b]pyridines bind to the ATP-binding site of PIKfyve, although with a different binding mode from that of the 3,6- disubstituted isothiazolo[4,3-b]pyridines.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1838785</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1838785</link>
        <title><![CDATA[Microwave-assisted technologies for recycling and regeneration of spent lithium-ion batteries]]></title>
        <pubdate>2026-05-07T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Jiawei Wu</author><author>Shaodong Yang</author><author>Sihua Jiang</author><author>Hongtao Cui</author><author>Jiali  Fu</author><author>Shijie Gu</author><author>Zhan Liu</author><author>Min Hong</author><author>Yuanlong Liu</author><author>Tiefeng Liu</author>
        <description><![CDATA[The rapid growth of lithium-ion battery (LIB) deployment in electric vehicles and energy storage systems has led to an increasing volume of end-of-life batteries, highlighting the urgent need for efficient and sustainable recycling technologies. Microwave thermal treatment has recently emerged as a promising approach for LIB recycling due to its unique internal heating mechanism, rapid heating rate, and high energy efficiency. This review systematically summarizes the recent progress of microwave-assisted technologies in the recycling and regeneration of spent LIB materials. The fundamental principles of microwave-matter interaction are first introduced, followed by a comprehensive discussion of its applications in key recycling processes, including pretreatment, carbothermal reduction, and hydrometallurgical leaching. Microwave heating can significantly accelerate the decomposition of binders, enhance reduction reactions, and improve leaching kinetics, thereby enabling faster metal recovery with lower energy consumption. In addition, microwave-assisted strategies for the direct regeneration of degraded electrode materials, such as graphite anodes and cathode materials (e.g., LiCoO2 and LiFePO4), are highlighted. Overall, microwave technology provides an energy-efficient and low-carbon pathway for the high-value recycling of spent LIBs and represents a promising direction toward establishing sustainable battery recycling systems.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1796912</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1796912</link>
        <title><![CDATA[An In silico analysis on the phosphorylation dependent structural and thermal stability of thermophilic proteins]]></title>
        <pubdate>2026-05-06T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Sermarajan Arunachalam</author><author>Ramachandran Gnanasekaran</author>
        <description><![CDATA[In the present study the effect of phosphorylation on the structural stability and energy transfer in two structurally homologous thermophilic proteins, 1QMP and 1DZ3 were investigated. In 1QMP one of the residues (Asp55) phosphorylated while 1DZ3 this modification is not observed. This modification has provided an ideal model to explore the influence of phosphorylation on thermostability of the protein. Molecular dynamics (MD) simulations were performed to assess the structural stability and flexibility of both proteins following the analyses of root-mean-square deviation and root-mean-square fluctuation (RMSF). Subsequent, vibrational energy transfer calculations were followed to characterize pathways of intramolecular energy propagation and also to evaluate the effect of phosphorylation via residue level communication within the protein matrix. The key residues and interaction networks involved in energy transport were visualized through communication maps, provided insights into influence of phosphorylation on intramolecular energy flow and also on the overall structural stability. Furthermore, steered molecular dynamics simulation were carried out to reveal the unfolding mechanism and thermal resistance of the proteins under the influence of applied force. The results have revealed that the 1QMP possess higher structural rigidity, enhanced energy transport efficiency, and greater resistance to unfolding as compared to 1DZ3. Overall, phosphorylation at Asp55 strengthens vibrational energy transfer pathways and contributes to the enhanced thermostability of thermophilic proteins.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1827333</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1827333</link>
        <title><![CDATA[Phosphorus recovery from high-COD and strongly acidic wastewater by vivianite crystallization: feasibility and optimization of operating conditions]]></title>
        <pubdate>2026-05-04T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Kai Cui</author><author>Guangyu Xu</author><author>Fei Ma</author><author>Hong Zhang</author><author>Jiahao Cao</author><author>Yan Yi</author><author>Kun Guo</author>
        <description><![CDATA[Acidified oil wastewater contains high concentrations of phosphorus and organic pollutants, which not only pose environmental risks but also contain recoverable phosphorus resources. However, its complex matrix (high COD and acidic environment) poses great challenges to phosphorus recovery technologies. This study successfully developed a new phosphorus recovery strategy adapted to the wastewater characteristics and optimized key operating parameters using response surface methodology. Key parameters including pH, Fe:P molar ratio, reaction time and residence time were investigated, clarifying their regulatory roles in the complex wastewater system. Under the optimal process conditions (pH = 7.77, Fe:P molar ratio = 2.24, reaction time = 2.23 h, and hydraulic residence time = 4.16 h), the phosphorus recovery rate reached 93.54%, and the vivianite crystallization rate reached 91.39%. Furthermore, a process parameter prediction model (the verification results and the model prediction was less than 2.1%) was established to produce vivianite crystallization with large particle size (d50 = 113.4 μm) and uniform morphology, realizing synchronous wastewater treatment and phosphorus recovery. This study confirmed the feasibility and controllability of phosphorus recovery through vivianite crystallization in complex acidified oil wastewater matrices, providing a sustainable technical path for addressing the dual issues of phosphorus resource shortage and environmental pollution.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1807712</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1807712</link>
        <title><![CDATA[Lipidated peptides and the limits of chemical control]]></title>
        <pubdate>2026-05-04T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Cesar Augusto Roque-Borda</author><author>Anamika Sharma</author><author>Fernando Rogério Pavan</author><author>Beatriz G. de la Torre</author><author>Fernando Albericio</author>
        <description><![CDATA[Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritically as evidence of improved molecular design. This Perspective highlights that lipidation can reshape peptide behaviour by partially shifting functional control from sequence-encoded molecular recognition toward context-dependent effects in which membrane interactions, carrier binding, supramolecular assembly, and residence time play an increasingly important role. Under such design-dependent conditions, enhanced activity may primarily reflect delivery- and exposure-driven amplification rather than improved intrinsic efficacy. While MIC values and endpoint assays remain valuable benchmarks of activity, they are insufficient on their own to guide rational optimization of lipidated peptides, as they conflate intrinsic activity with lipid-driven distribution and time-dependent effects. Accordingly, this Perspective argues not against lipidation itself, but for reframing lipidation as a deliberately controllable interaction element rather than a generic potency modifier, thereby restoring mechanistic interpretability and design robustness in peptide chemical biology.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1852717</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1852717</link>
        <title><![CDATA[Correction: Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Correction</category>
        <author>Gbolahan O. Oduselu</author><author>Rhoda O. Olatuyi</author><author>Omowunmi O. Fatoki</author><author>Damilola S. Bodun</author><author>Promise E. Sunday</author><author>Wellington Oyibo</author><author>Olayinka O. Ajani</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1814633</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1814633</link>
        <title><![CDATA[Underwater drag reduction via self-healing and robust air plastrons stabilized by candle soot-based coatings]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Muhammad Imran Jamil</author><author>Arshia Komal</author><author>Mehboob Hassan</author><author>Mazloom Shah</author><author>Waqar Ahmed</author><author>Hafiz Muhammad Ali</author><author>Numan Ahmed</author><author>Fazal Haq</author><author>Sahid Mehmood</author><author>Shahid Iqbal</author><author>Meznah M. Alanazi</author><author>Shaimaa A. M. Abdelmohsen</author>
        <description><![CDATA[In marine environments, the increased drag force on vehicles impedes their speed underwater, leading to high energy consumption and reduced vehicle efficiency. Superhydrophobic coatings have gained remarkable attention regarding drag reduction. Due to the collapse of the air plastron, the change from Cassie–Baxter to Wenzel state at high fluid impalement pressures, and various chemical conditions, these coatings lose their ability to reduce drag in cold marine settings. Candle soot nanoparticles are deposited into an elastic binder to create a strong, environmentally friendly porous superhydrophobic covering with healable plastron to solve these difficulties. The interconnected nano-pores of the soot particles retain the drag reduction performance by robustly maintaining the air plastron under water. The water droplets bouncing on elastic soot coating cause drag reduction by reducing their contact time. The soot-coated copper ball enfolds the gas cavity volume 14.83 times greater than that of the bare ball while impacting water. The near-zero drag coefficient values of the soot-coated copper sphere confirm its efficient drag reduction performance. In Taylor-Couette flow, the soot-coated rotor showed a 60% drag reduction as compared to the bare rotor. The rheological experiments showed a 15.26% reduction in the apparent viscosity of glycerol and a 13.86% shear stress reduction on soot coated surface at −10 °C. The soot-coated boat covered 31 cm more distance at high speed than the uncoated boat. The plastron of candle soot coating showed stability under lake water, pond waters, super-cold water, liquid nitrogen, acidic and basic media, artificial seawater, different organic solvents, and sand abrasion. Moreover, a soot-coated aluminium plate floated on the surface of water while bearing a load. The durability, passive plastron stability, and self-cleaning of candle soot superhydrophobic coating have the potential for efficient drag reduction and are suitable for large-scale applications even in arctic environments in order to improve the fuel efficiency and substantial energy savings.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1861325</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1861325</link>
        <title><![CDATA[Editorial: New trends in green chemistry: sustainable and alternative strategies for the extraction of high-value compounds from agri-food matrices and residues]]></title>
        <pubdate>2026-04-30T00:00:00Z</pubdate>
        <category>Editorial</category>
        <author>Francesca Annunziata</author><author>Gigliola Borgonovo</author><author>Patricia Rijo</author><author>Andrea Pinto</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1790752</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1790752</link>
        <title><![CDATA[Diol-enhanced natural deep eutectic solvents for efficient poplar pretreatment]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Chaehwi Yoon</author><author>Jiae Ryu</author><author>Soyeon Jeong</author><author>Aymerick Eudes</author><author>Kwang Ho Kim</author><author>Chang Geun Yoo</author>
        <description><![CDATA[Natural deep eutectic solvents (NDESs) are promising biomass pretreatment media, but their industrial application is often hindered by high viscosity. To address this limitation, diol-enhanced ternary DESs (TDESs) were prepared by incorporating 1,4-butanediol (1,4-BDO) or ethylene glycol (EG) into a choline chloride (ChCl) and 3,4-dihydroxybenzoic acid (DHBA) system. The applied TDESs maintained a liquid state at room temperature and had significantly reduced viscosity compared to the binary DES (BDES). In addition, the applied diols increased lignin solubility and suppressed lignin condensation by intercepting reactive carbocation intermediates. As a result, the recovered lignins from diol-induced TDES pretreatments showed better preservation of β-O-4 linkages and reduced condensation, improving their potential for downstream valorization. The diol-assisted DES systems showed a synergistic effect from the reduced viscosity, enhanced lignin solubility, and suppression of unwanted condensation, resulting in more effective biomass pretreatment performance, including the enhanced delignification and higher enzymatic digestibility compared to BDES. The 1,4-BDO-enhanced DES was also successfully applied to DHBA-enriched transgenic poplar, highlighting its potential for the processing of engineered biomass feedstocks.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/fchem.2026.1800775</guid>
        <link>https://www.frontiersin.org/articles/10.3389/fchem.2026.1800775</link>
        <title><![CDATA[Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Mohamed F. Zayed</author><author>Yosra Muhammad</author><author>Aymen A. Alqurain</author><author>Mohammed A. A. Banafa</author><author>Abdelsattar M. Omar</author>
        <description><![CDATA[IntroductionFive new quinazoline-sulfonamide hybrids 4a (MZ-13), 4b (MZ-20), 4c (MZ-25), 4d (MZ-26), and 6a (MZ-29) were designed, synthesized, and investigated for their in vitro and in vivo antidiabetic activities.MethodsThe in vivo screening was conducted in a mouse model of type II diabetes induced by streptozotocin (STZ), using glibenclamide as the positive control. The in vitro model was performed by measuring the activity of these compounds against the PPARγ enzyme. Furthermore, the total antioxidant capacity (TAC) was measured for these compounds to assess their ability to neutralize a wide range of free radicals. A physicochemical study was conducted to demonstrate the drugability of these compounds. Additionally, the in silico ADMET and toxicity studies illustrated good pharmacokinetic properties and a low toxicity profile. Likewise, a comprehensive molecular modeling study was performed to examine the binding modes of the new compounds.ResultsCompound MZ-29 showed 27.1% reduction in blood glucose (BG) levels, and the standard glibenclamide showed 17.2% reduction in BG. The in vitro assay of the compounds MZ-13 and MZ-29 demonstrated superior or comparable activity to the reference glibenclamide.DiscussionThe study identified MZ-29 and MZ-26 as the most promising candidates in the series. These two compounds achieved docking scores and binding orientations closely mimicking the native ligand.]]></description>
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