AUTHOR=Wang Yifan , Wang Xinni , Voyer Chloé , Brunet Alain , Ateba François Freddy , Wazana Ashley , Laplante David P. TITLE=Interactive effects of prenatal adversity and COVID-19 hardship on youth psychological distress: a longitudinal study JOURNAL=Frontiers in Child and Adolescent Psychiatry VOLUME=Volume 4 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/child-and-adolescent-psychiatry/articles/10.3389/frcha.2025.1581135 DOI=10.3389/frcha.2025.1581135 ISSN=2813-4540 ABSTRACT=IntroductionThe COVID-19 pandemic resulted in severe loss of life and increased anxiety as well as fear worldwide. This study explored whether pre-pandemic exposure to varying levels of perinatal maternal adversity coupled with pandemic-related experiences are related to youth distress levels.MethodsData from 119 youth (aged 9–17) and their mothers were analyzed to assess the interactive effects of perinatal maternal adversity and pandemic-related objective hardship on youth psychological distress.ResultsYouth-reported hardship models consistently explained more variance in their psychological distress. Youth-reported hardship, specifically daily life changes, predicted psychological distress, including PTSD symptoms and peritraumatic experiences during the pandemic.DiscussionYouths exposed to high perinatal maternal socio-environmental adversity demonstrated resilience when faced with pandemic disruptions, suggesting that alignment between early adversity and later stress can mitigate distress during crises.