AUTHOR=Bass Sarah Bauerle , Chertock Yana , Brajuha Jesse , Kelly Patrick J. A. , Rotaru Alexandru-Mircea , D’Avanzo Paul , Hoadley Ariel , Luck Caseem , Singley Katie , Hall Michael J. TITLE=Development and user testing of gene pilot: an electronic health decision support tool for Black cancer patients about tumor genomic profile testing JOURNAL=Frontiers in Communication VOLUME=Volume 10 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/communication/articles/10.3389/fcomm.2025.1505456 DOI=10.3389/fcomm.2025.1505456 ISSN=2297-900X ABSTRACT=IntroductionTumor genomic profiling (TGP) is used to optimize cancer treatment but is underutilized by Black patients, despite having disproportionately higher cancer morbidity and mortality. No interventions using electronic health decision support tools (eHealth DSTs) have been developed to assist patients with understanding this test or address barriers to uptake and communicating preferences with a doctor.MethodsUsing the Ottawa Decision Support Framework, we systematically developed the Gene Pilot eHealth DST with Black cancer patients. We conducted qualitative focus groups (five groups, N = 33) and surveys (N = 121), elicited community advisory board feedback (N = 10) to devise DST content and communication strategies, and then conducted user testing (N = 10). Content was informed by commercial marketing techniques - segmentation, perceptual mapping, vector message modeling – to elucidate how medical mistrust was an important construct to address in Gene Pilot.ResultsUser testing (1–7 scale) indicated Gene Pilot was highly accepted, including ease of use (M = 6.67, SD = 0.50), that it addressed important barriers such as medical mistrust and genetic literacy (6.63, SD = 0.52), and allowed patients to prepare for the decision (M = 6.44, SD = 0.73) and to communicate with their doctor (M = 6.33, SD = 0.73). Suggestions for improved navigability were addressed.ConclusionOverall, Gene Pilot was found to be acceptable, suggesting its readiness for efficacy testing.