AUTHOR=Borges Ligia F. , Barros Michael T. , Nogueira Michele 

TITLE=Cell signaling error control for reliable molecular communications

JOURNAL=Frontiers in Communications and Networks

VOLUME=Volume 5 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/communications-and-networks/articles/10.3389/frcmn.2024.1332379

DOI=10.3389/frcmn.2024.1332379

ISSN=2673-530X

ABSTRACT=Molecular communication (MC) allows implantable devices to communicate using biological datatransmission principles (e.g., molecules as information carries). However, MC faces significant challenges due to molecular noise, which leads to increased communication errors. Thus, error control techniques become critical for reliable intra-body networks. The noise management and error control in these networks must be based on the characterization of the environment dynamics, i.e., characteristics that increase noise, such as the stochastic behavior of the intercellular channels and the presence of pathologies that affect communication. This work proposes an adaptive error control technique for cell signalling-based MC channels (CELLEC).Using an information-theoretic approach, CELLEC mitigates errors in cellular channels with varying noise conditions. The characteristics of the cellular environment and different noise sources were modeled to evaluate the proposal. The additive white Gaussian tissue noise (AWGTN) produced by stochastic chemical reactions is theorised for healthy cells. The MC model also considers the noise of cells affected by one pathology that disrupts cells' molecular equilibrium and causes them to become reactive (i.e., Alzheimer's disease). Analyses show that reactive cells have a higher signal-to-noise ratio (21.4%) and path loss (33.05%) than healthy cells, highlighting the need for an adaptive technique to deal with cellular environment variability.Results show that CELLEC improves communication channel performance by lowering the bit error rate (18%).