AUTHOR=Shaheen Hina , Singh Sundeep , Melnik Roderick 

TITLE=A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2021.653097

DOI=10.3389/fncom.2021.653097

ISSN=1662-5188

ABSTRACT=Exosomes are nano-sized extracellular vesicles that perform a variety of biological functions linked to the pathogenesis of various neurodegenerative disorders. In Alzheimer's disease, for example, exosomes are responsible for the release of amyloid-beta oligomers, and their extracellular accumulation, although the underpinning molecular machinery remains elusive. We propose a novel model for Alzheimer's amyloid-beta accumulation based on calcium-dependent exosome release from astrocytes. Moreover, we exploit our model to assess how temperature dependence of exosome release could interact with amyloid-beta neurotoxicity. We predict that voltage-gated calcium channels along with the transient-receptor potential M8 channel are crucial molecular components in Alzheimer's progression.