AUTHOR=Maxion Anna , Kutafina Ekaterina , Dohrn Maike F. , Sacré Pierre , Lampert Angelika , Tigerholm Jenny , Namer Barbara 

TITLE=A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2023.1265958

DOI=10.3389/fncom.2023.1265958

ISSN=1662-5188

ABSTRACT=Patients with small fiber neuropathy (SFN) suffer from neuropathic pain, which is still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral nerve fibers (CMi) could cause neuropathic pain. However, there is sparse knowledge about mechanisms leading to CMi dysfunction since it is difficult to dissect specific molecular mechanisms in humans. We used an in-silico model to elucidate molecular causes of CMi dysfunction as observed in single nerve fiber recordings (microneurography) of SFN patients.