AUTHOR=Roeder Brent M. , She Xiwei , Dakos Alexander S. , Moore Bryan , Wicks Robert T. , Witcher Mark R. , Couture Daniel E. , Laxton Adrian W. , Clary Heidi Munger , Popli Gautam , Liu Charles , Lee Brian , Heck Christianne , Nune George , Gong Hui , Shaw Susan , Marmarelis Vasilis Z. , Berger Theodore W. , Deadwyler Sam A. , Song Dong , Hampson Robert E. 

TITLE=Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=Volume 18 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2024.1263311

DOI=10.3389/fncom.2024.1263311

ISSN=1662-5188

ABSTRACT=Objective-Here, we demonstrate the first successful use during neural stimulation of static patterns for specific information content that were derived by models that were applied to a subject's own hippocampal spatiotemporal neural codes for memory. Here, we demonstrate the first successful use of static neural stimulation patterns for specific information content. These static patterns were derived by a model that was applied to a subject's own hippocampal spatiotemporal neural codes for memory.Approach-We constructed a new model of processes by which the hippocampus encodes specific memory items via spatiotemporal firing of neural ensembles that underlie the successful encoding of targeted content into short-term memory. A memory decoding model (MDM) of hippocampal CA3 and CA1 neural firing was computed which derives an activation a stimulation pattern offor CA1 and CA3 neurons to be applied during the encoding (sample) phase of a delayed match-to-sample (DMS) human short-term memory task.Main results-MDM electrical stimulation delivered to the CA1 and CA3 locations in the hippocampus during the sample phase of DMS trials facilitated memory of images from the DMS task during a delayed recognition (DR) task that also included control images that were not from the DMS task. Across all subjects, the stimulated trials exhibited significant changes in performance in 22.4% of patient and category combinations. Changes in performance were a combination of both spatiotemporal codes are able to modify memory performance in a content specific manner. This offers an alternate, and possibly complimentary, method of stimulation for use in a hippocampal prosthetic than that previously demonstrated.