AUTHOR=Syauqie Muhammad , Patria Harry , Hastono Sutanto Priyo , Siregar Kemal Nazaruddin , Moeloek Nila Djuwita Farieda TITLE=Deep learning for vision screening in resource-limited settings: development of multi-branch CNN for refractive error detection based on smartphone image JOURNAL=Frontiers in Computer Science VOLUME=Volume 7 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/computer-science/articles/10.3389/fcomp.2025.1576958 DOI=10.3389/fcomp.2025.1576958 ISSN=2624-9898 ABSTRACT=IntroductionUncorrected refractive errors are a leading cause of preventable vision impairment globally, particularly affecting individuals in low-resource regions where timely diagnosis and screening access remain significant challenges despite the availability of economical treatments.AimThis study introduces a novel deep learning-based system for automated refractive error classification using photorefractive images acquired via a standard smartphone camera.MethodsA multi-branch convolutional neural network (CNN) was developed and trained on a dataset of 2,139 corneal images collected from an Indonesian public eye hospital. The model was designed to classify refractive errors into four categories: significant myopia, significant hypermetropia, insignificant refractive error, and not applicable to classified. Grad-CAM visualization was employed to provide insights into the model’s interpretability.ResultsThe 3-branch CNN architecture demonstrated superior performance, achieving an overall test accuracy of 91%, precision of 96%, and recall of 98%, with an area under the curve (AUC) score of 0.9896. Its multi-scale feature extraction pathways were pivotal in effectively addressing overlapping red reflex patterns and subtle variations between classes.ConclusionThis study establishes the feasibility of smartphone-based photorefractive assessment integrated with artificial intelligence for scalable and cost-effective vision screening. By training the CNN model with a real-world dataset representative of Southeast Asian populations, this system offers a reliable solution for early refractive error detection with significant implications for improving accessibility to eye care services in resource-limited settings.