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        <title>Frontiers in Dementia | New and Recent Articles</title>
        <link>https://www.frontiersin.org/journals/dementia</link>
        <description>RSS Feed for Frontiers in Dementia | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-05-03T16:29:30.867+00:00</pubDate>
        <ttl>60</ttl>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1790741</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1790741</link>
        <title><![CDATA[What needs to be addressed in caring for people living with dementia? A multi-faceted evidence on financial, psychological, and physical health issues in dementia care]]></title>
        <pubdate>2026-05-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Ben Gould</author><author>Smruti Bulsari</author><author>Mariachiara Di Cesare</author>
        <description><![CDATA[BackgroundDementia is a progressive neurodegenerative condition with 60.2 million cases worldwide. The disease has financial, psychological, and physical health implications for people affected and their carers. There is a dearth of literature exploring financial issues experienced by carers and persons living with dementia beyond the loss of income, while psychological implications have been studied in silos, and physical health implications have mostly focused on sleep deprivation. Our study aims to provide multi-faceted evidence on all three issues experienced by persons living with dementia and their carers.MethodsSemi-structured interviews, congruent with the social constructivist framework, were administered, recorded on Microsoft Teams, and transcribed for eight carers, four persons living with dementia excepts, and one participant who was both a carer and a person living with dementia. Participants were recruited using a purposive sampling approach through the local community-led friendly cafe groups in Essex. Transcripts were anonymised, and thematic analysis was undertaken.ResultsResponses of the carers revealed concerns about the future financial situation, the expenses on respite care, and replacing the household equipment. Psychological implications for carers included a change in role from partner to carer, resulting in loneliness, loss of friends, coping with the deterioration in behaviour of the person living with dementia except, and relentlessness of care. One major physical health implication identified was exhaustion and the need to extend physical support, such as lifting the person living with dementia from a fall. Persons living with dementia hardly expressed concerns on the financial implications, though they narrated denial of diagnosis, feeling of loss of independence, and the changes in behaviour associated with dementia, among the psychological implications. The physical implications of the persons living with dementia largely included physical deterioration. Other issues, including feeling at loss of access to information, post-diagnostic medical support, and designs of public toilets, were also elicited from the interviews.ConclusionGiven the interdependent nature of the issues experienced by persons living with dementia and their carers, an integrated approach to post-diagnostic support for information dissemination, counselling, and training for carers could help reduce both the physical and mental burden of dementia on patients and carers.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1730124</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1730124</link>
        <title><![CDATA[Cognitive and brain volume correlates of financial literacy assessment in Greek persons with amnestic Mild Cognitive Impairment: a preliminary study]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Vaitsa Giannouli</author>
        <description><![CDATA[BackgroundFinancial literacy is a crucial skill for the aging population. However, so far we have no data coming from Greece regarding financial literacy and cognitive and brain correlates in healthy older adults and amnestic Mild Cognitive Impairment (aMCI) patients.MethodsIn this preliminary study, financial literacy was examined with the Big Three Questions in 15 individuals with aMCI and 15 matched healthy controls. Simultaneous measurements of different regional brain volumes were derived from structural MRI and the cognitive performance was assessed with a number of standardized neuropsychological tests (Rey auditory verbal learning test, clock drawing test trail-making test parts A and B, Boston Naming Test, digit span memory test forward and backward, and verbal fluency task).ResultsFor the first time, findings suggest lower financial literacy in aMCI compared to matched controls. Spearman correlations revealed that financial literacy correlates with a number of brain volumes (white matter, gray matter, left amygdala, and right frontal medial cortex). Among the cognitive tests, correlations were found only with trail making parts A and B time to completion.ConclusionThe above findings are of importance for clinicians as indicators of need for comprehensive financial capacity assessment of older patients susceptible to financial exploitation.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1805579</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1805579</link>
        <title><![CDATA[Spontaneous conversations as data in young-onset dementia research: a qualitative study]]></title>
        <pubdate>2026-04-29T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Martina Quartarone</author><author>Ludovica Forte</author><author>Lara Calabrese</author><author>Marco Brigiano</author><author>Alice Annini</author><author>Sara Trolese</author><author>Giorgia Vella</author><author>Francesca Vaienti</author><author>Manuela Boschetti</author><author>Rabih Chattat</author>
        <description><![CDATA[BackgroundYoung-onset dementia (YOD), defined by symptom onset before the age of 65, profoundly impacts personal identity, work, and family life. Despite growing interest in the psychosocial dimensions of YOD, the direct voices of people living with the condition remain underrepresented. Existing qualitative research has mainly relied on structured interviews, which can constrain spontaneity and the emergence of authentic meanings. This study adopts an innovative approach by analyzing spontaneous conversations as a naturalistic form of data, enabling a more ecological understanding of living experience.MethodsAn exploratory qualitative study was conducted at an Italian Meeting Center for people with YOD. Eleven participants (aged 55-68) took part in 14 naturally occurring group conversations, recorded between October 2024 and February 2025. Transcripts were analyzed using the General Inductive Approach. Themes were co-developed through iterative coding and later validated in a participatory feedback session involving all participants.FindingsFour overarching themes were identified: (1) Living with Alzheimer's: between awareness and “broad shoulders”—redefining identity and meaning in everyday life; (2) Significant relationships: between closeness, misunderstanding, and new balances—navigating relational change and finding belonging in peer groups; (3) The struggle to be believed: between invisible illness and judging gazes—confronting stigma, disbelief, and social invisibility; (4) Support that makes a difference: between resources and ideas for living better—valuing respectful, personalized, and co-designed support. Participants collectively emphasized the need to move from a “for” to a “with” logic in dementia care and research:“It is not enough to do something for us. We need to build it together.”ConclusionsSpontaneous conversations offer a powerful lens to capture the nuanced, relational, and participatory aspects of living with young-onset dementia. This approach complements traditional qualitative methods by restoring authenticity to the voices of people with dementia, fostering inclusion, and informing the co-construction of more responsive psychosocial and community interventions.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1791795</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1791795</link>
        <title><![CDATA[Multimorbidity research in dementia: it’s time to shift to a person-centred approach]]></title>
        <pubdate>2026-04-22T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Subhashisa Swain</author><author>Kumud Kantilal</author><author>Vidyani Suryadevara</author><author>Lucy E. Stirland</author>
        <description><![CDATA[People with dementia often live with several long-term conditions (known as multimorbidity). These conditions interact with dementia in complex ways and influence symptoms, care needs, and quality of life. Current researches are primarily divided into quantitative or qualitative methods without complementing each other. Most data driven research usually counts diagnoses or groups diseases. Qualitative evidence shows the need, and how daily routines, family roles, and personal goals affect care. These methods do not explain how people manage other long-term conditions alongside dementia. As a result, research findings do not always support care that centres on what matters to individuals. This paper proposes a shift in research on multimorbidity in people with dementia. Unlike other conditions, dementia is often diagnosed in later stage of life, with high burden of multimorbidity. We argue that data base research should focus on symptoms, function, treatment workload, and social context, which could shape how people live with dementia and multimorbidity. It can also inform the transitions between home, hospital, community services, and long-term care. These insights can guide the design of interventions that fit real situations. For evidence generation on symptom-based measures, functional assessments, and patient-reported outcomes, mixed methods studies can show how context, mechanisms, and outcomes interact. We offer a research agenda that places the person at the centre and what works for the patient going beyond the simple disease burden. This agenda supports the development of care that is feasible, acceptable, and meaningful. Without this shift, multimorbidity research may not improve everyday dementia care.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1845196</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1845196</link>
        <title><![CDATA[Correction: Louise Snowball, room #237: exhibiting a multisensory mixed-media installation at a scientific dementia conference]]></title>
        <pubdate>2026-04-20T00:00:00Z</pubdate>
        <category>Correction</category>
        <author>Ellen Snowball</author><author>Zoe Dempster</author><author>Inbal Itzhak</author><author>Jennifer Bethell</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1791588</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1791588</link>
        <title><![CDATA[Evaluating a co-developed pet robot intervention and implementation for residents with dementia in long-term care]]></title>
        <pubdate>2026-04-17T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Wei Qi Koh</author><author>Tracy Carroll</author><author>Letetia Gimblett</author><author>Ellen Murphy</author><author>Nicole Gavin</author>
        <description><![CDATA[BackgroundPet robots have the potential to improve the wellbeing of people living with dementia, particularly in residential care contexts. Despite increasing interest in their use and a body of research investigating their impact and effectiveness, more research is needed to support their translation into dementia care practice. This paper reports on the co-development and evaluation of a pet robot intervention and its implementation in a residential aged care facility to support the psychosocial wellbeing of residents living with dementia.MethodsA pet robot intervention protocol and implementation strategies were co-developed in consultation with key stakeholders from a residential aged care facility. Purposive sampling was used to recruit participants (residents) living with dementia. The pet robot intervention was delivered up to three times a week, for up to 30 min each time over a 6-week period. Following the intervention, residents with dementia, their family members and staff involved in delivering the intervention were invited to participate in a semi-structured interview to understand their experiences and perceptions of the impact of the intervention and its implementation. Interviews were audio-recorded, transcribed and analysed using content analysis.ResultsEight residents with dementia had consented to participate, however one had passed away before the intervention commenced. At the end of the intervention period, eight participants including five residents, one family member and two staff consented to participate in the semi-structured interviews. Four key themes were generated: (1) perceptions of the attributes of pet robots, (2) opening doors: facilitating connections and participation, (3) integrating pet robots into routine care, and (4) moving forward: maximising impact and sustainability.ConclusionThis study demonstrates the feasibility and potential impact of a 6-week pet robot intervention and implementation in a RACF facility to support residents living with dementia. Findings provide insights into strategies that might increase the routinisation of pet robots in dementia care; future studies could consider further refining, enhancing and formally evaluating these strategies.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1820253</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1820253</link>
        <title><![CDATA[Reimagining U.S. social care policy: a commentary on Medicaid strategies to better support individuals with dementia]]></title>
        <pubdate>2026-04-16T00:00:00Z</pubdate>
        <category>Opinion</category>
        <author>Alice Boughrum</author><author>Amy Lastuka</author><author>Nicole Batsch</author><author>Victoria Helmly</author><author>Mary Manchester</author><author>Lillian Morgado</author><author>Romil R. Parikh</author><author>Mary Louise Pomeroy</author><author>Audrey Price</author><author>Michael Splaine</author><author>Raven H. Weaver</author><author>William Zagorski</author><author>Regina A. Shih</author>
        <description></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1791608</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1791608</link>
        <title><![CDATA[Palliative care conversations with people with dementia who live alone: untapped dimensions from a lived experience]]></title>
        <pubdate>2026-04-15T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Lesley E. Williamson</author><author>Dawn Horne</author><author>Rasa Mikelyte</author><author>Elisabeth B. Grey</author><author>Pippa Collins</author><author>Christopher Poyner</author><author>Annabel Farnood</author><author>Tomasina M. Oh</author>
        <description><![CDATA[Dementia is a life-limiting condition, and a palliative care approach can improve both quality of life and quality of care for people living—and dying—with dementia. Research has consistently shown that, compared with other terminal conditions such as cancer, dementia is under-recognised and under-treated within palliative care systems. Considerable attention has been paid to this overall under-representation; however, further inequities exist within palliative dementia care research and practice itself. This position paper draws on an in-depth conversation with a person living alone with Alzheimer’s disease and vascular dementia, alongside a critical engagement with existing literature. Using lived experience as a starting point, we identify two untapped dimensions of palliative dementia care: (1) barriers in palliative care conversations when a person with dementia attends clinical appointments unaccompanied; and (2) intersectional disadvantage arising from dementia, living alone, and health and social care systems that overly rely on informal carers or supporters. These contribute to exclusionary research practices that marginalise people living with dementia without close care partners. While the involvement of carers and supporters in shared decision-making should be encouraged when they are present, high-quality palliative care and research must not depend on their presence and should be equally accessible to people living with dementia who attend services alone. We argue that addressing this neglected area requires the meaningful involvement of people with lived experience in shaping both research agendas and clinical practice.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1785124</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1785124</link>
        <title><![CDATA[Amyotrophic lateral sclerosis and chronic inflammatory demyelinating polyneuropathy coexistence in a patient with a C9orf72 variant: case report]]></title>
        <pubdate>2026-04-13T00:00:00Z</pubdate>
        <category>Brief Research Report</category>
        <author>Christopher File</author><author>Anthony M. Price</author><author>Rowaid Ahmad</author><author>Elena Shanina</author><author>Ruiqing L. Sun</author>
        <description><![CDATA[BackgroundThe C9orf72 variation has been strongly implicated in the inheritance of familial ALS, frontotemporal dementia (FTD), and combined ALS-FTD cases. Increasing evidence implicates immune changes and inflammation in some ALS patients. Several studies demonstrated that ALS coexists with CIDP or polyneuropathy. Mouse models of C9orf72 loss-of-function mutations exhibit fatal immune dysregulation.Case summaryA 62-year-old Caucasian man developed right foot drop, and he underwent fibular nerve release without significant improvement. At the same time, he developed progressive weakness and numbness in his bilateral hands. MRI revealed cervical canal stenosis and neuroforaminal narrowing that prompted neurosurgical decompression without clinical improvement. Subsequently, he developed left foot drop. At the clinic presentation, he exhibited dysarthria, tongue fasciculations, weakness in all extremities, muscle atrophy, widespread fasciculations, and upper extremity hyperreflexia, meeting clinical criteria for ALS. Genetic testing identified a pathogenic variant in the C9orf72 gene, confirming a C9orf72 variant, commonly linked to familial ALS. Brain MRI demonstrated the motor band sign. Although EMG/NCS findings were consistent with lower motor neuron disease, he also had signs of demyelinating polyneuropathy based on conduction parameters. Neuromuscular ultrasound showed significant multifocal nerve enlargement typical of immune-mediated neuropathy. CSF studies revealed albuminocytologic dissociation (protein: 112 mg/dL, with normal cell count) and high albumin quotient and index. He fulfilled the 2021 EAN/PNS criteria for possible typical CIDP. He was treated with intravenous immunoglobulin in addition to riluzole with temporary improvement.ConclusionThis is the first case of the co-existence of CIDP and ALS in the setting of a pathogenic C9orf72 variant.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1799514</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1799514</link>
        <title><![CDATA[A qualitative study to create a framework of Métis understandings of brain health promotion and dementia prevention in Alberta, Canada]]></title>
        <pubdate>2026-04-13T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Shanaya Fischer</author><author>Meagan Ody</author><author>Lisa Zaretsky</author><author>Jennifer D. Walker</author><author>Pamela Roach</author>
        <description><![CDATA[BackgroundIndigenous populations experience a higher prevalence of dementia compared to non-Indigenous populations. Brain Health PRO is a web-based educational program designed to increase knowledge around dementia risk factors and help create lifestyle changes. The purpose of this study is to understand whether Brain Health PRO is relevant to Métis communities in Alberta, Canada.MethodsMétis participants were recruited across Alberta and interviews were completed using the Métis visiting methodology (Keeoukaywin). Data were co-analysed using Indigenous approaches to reflexive thematic analysis.ResultsSixty-three interviews with 20 participants were completed between April and November 2024. The analysis generated two main themes which suggest the overall design and delivery of Brain Health PRO are not culturally relevant for Métis people in Alberta. The first theme, “Promoting Métis knowledge systems” was demonstrated through discussions of the seven components of Brain Health PRO (physical health, cognitive engagement, nutrition, sleep, social and psychological health, vascular health, and vision and hearing), and how these components excluded traditional Métis knowledge. The second theme, “Holistic approaches to risk reduction” described the how Métis knowledge could influence the way each component is presented and understood together in a Métis worldview. The subthemes were: importance of interaction and balance of multiple components; benefits of in-person program delivery; brain health promotion across the lifespan; accessing resources; and the legacy of colonization.DiscussionThough the seven components of Brain Health PRO may be useful for Métis people, the content and delivery of these components lacked Métis knowledge and worldviews. In-person engagement with Métis communities is a crucial next step to co-develop resources that are culturally appropriate.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1797005</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1797005</link>
        <title><![CDATA[Extraordinary abilities, creativity, and love, in the path of dementia: a perspective article on the Walking the Talk for Dementia 2025 initiative]]></title>
        <pubdate>2026-04-13T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Madalena P. Liougas</author><author>Prabha Shrestha</author><author>Belen Custodio</author><author>Lenisa Brandao</author><author>Kevin Cullen</author><author>Therese Maher</author><author>Karen Young</author><author>Alan Young</author>
        <description><![CDATA[This manuscript, co-created by researchers and people living with dementia and their care partners, explores how engagement with lived experience can transform conventional, deficit-based understandings of dementia—often defined by what is lost. While clinically useful, this framing can obscure the richness, resilience, and relational depth present in the lives of people living with dementia. Drawing on a collaborative and reflective process inspired by participation in Walking the Talk for Dementia 2025—a global immersive event that brought together people with lived experience of dementia, researchers, advocates, clinicians, and artists—the paper challenges traditional narratives of dementia. Through in-person and virtual discussions and documented reflections, the team conducted a qualitative thematic analysis to identify key insights. Three themes emerged: (1) ‘Dementia Reimagined’, highlighting personal and professional transformation and new identities; (2) ‘Flourishing through Creativity and Resilience’, illustrating humor, creativity, leadership, and authentic connection; and (3) ‘Dementia as a Catalyst for Love and Understanding’, emphasizing enduring love and deepened empathy within families and communities. These findings demonstrate that living with dementia can foster resilience, creativity, and meaningful human connection. This experiential, co-produced approach reframes dementia beyond deficit-based models, offering transformative insights that can inform person-centered care practices, policy development, and increase awareness.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1791195</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1791195</link>
        <title><![CDATA[Artificial intelligence in dementia care: challenges, controversies, and policy implications]]></title>
        <pubdate>2026-04-10T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Natalia Vilor-Tejedor</author><author>Robert van Vorstenbosch</author><author>Tavia E. Evans</author>
        <description><![CDATA[Artificial intelligence (AI) is rapidly expanding into dementia-related health and social care, with proposed applications ranging from early risk detection and monitoring to care coordination and service planning. While these technologies may support independence, reduce caregiver burden, and improve efficiency in overstretched systems, dementia care is a uniquely high-stakes context for digital innovation. Cognitive decline can affect consent and agency, care often occurs in private domestic settings, and individuals may become increasingly dependent on others to interpret and act on algorithmic outputs. This Perspective examines the opportunities and challenges of AI in dementia policies and services, focusing on equity, privacy, accountability, and the risk that technologies displace human care. We argue that AI tools are only as reliable and fair as the data and infrastructures on which they depend, and that uneven access to digital resources may widen disparities in diagnosis, monitoring, and support. We also highlight often-overlooked considerations, including environmental sustainability and the broader role of AI in shaping exposures relevant to brain health across the life course. Whether AI improves dementia care will ultimately depend on policy and governance choices, including investment in equitable digital infrastructure, robust real-world validation, and safeguards that prevent technology from substituting for human care. Finally, we propose governance priorities to ensure that AI-enabled dementia innovations are implemented as a public-interest matter, grounded in meaningful engagement of people living with dementia and care partners, real-world validation, and safeguards that protect dignity, autonomy, and social legitimacy.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1768487</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1768487</link>
        <title><![CDATA[Evaluating the cognitive impact of exergames on community-dwelling older adults beyond laboratory settings: a systematic review and meta-analysis]]></title>
        <pubdate>2026-04-10T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>Yijun Qian</author><author>Anna M. Schwartz</author><author>Yichi Zhang</author><author>Arthur F. Kramer</author><author>Alexandre Dias Lopes</author><author>Leanne Chukoskie</author>
        <description><![CDATA[Cognitive decline in older adults is a growing global concern, with over 55 million people living with dementia worldwide. Exercise games, which combine physical exercise with cognitive training in an interactive digital environment, represent a promising approach for mitigating this decline in community settings. Here we present a systematic review and meta-analysis examining the cognitive effects of exercise games on community-dwelling older adults, including those with mild cognitive impairment and dementia. Across 10 randomized controlled trials with 690 participants (mean age 74 years), exercise games produced a small but statistically significant overall cognitive benefit compared to control conditions (Hedges' g = 0.135, 95% CI [0.037, 0.229], p = 0.012). Domain-specific analyses revealed memory showing a trend toward improvement (g = 0.179, p = 0.060), while global cognition, executive function, and attention did not reach statistical significance. A single study examining processing speed showed a positive effect, though this finding requires replication. Multicomponent exercise programs incorporating aerobic elements demonstrated numerically larger, though non-significant, effects (g = 0.291, p = 0.138) compared to aerobic-only interventions (g = 0.119, p = 0.142). The evidence base for clinical populations remains limited and inconclusive, with only two studies examining MCI (g = 0.256, p = 0.168) and three studies examining dementia (g = 0.005, p = 0.975), neither showing statistically significant effects. These findings provide preliminary evidence supporting exercise games as a modest, accessible supplementary intervention for cognitive health in community settings, though the small effect sizes and limited evidence in clinical populations indicate that substantially more research with larger samples and standardized protocols is needed to establish efficacy and optimize implementation.Systematic review registrationhttps://doi.org/10.17605/OSF.IO/AM8QT.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1719740</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1719740</link>
        <title><![CDATA[MRI evaluation of cerebral perivascular spaces predicts amyloid-related imaging abnormalities risk in preclinical Alzheimer's disease]]></title>
        <pubdate>2026-04-09T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Bavrina Bigjahan</author><author>Michele Cavallari</author><author>Giuseppe Barisano</author>
        <description><![CDATA[Background and purposeAmyloid-related imaging abnormalities (ARIA) are radiographic findings observed in the natural course of Alzheimer's disease and have been reported at higher rates in patients receiving anti-amyloid monoclonal antibody therapy. Identifying novel radiographic factors predicting ARIA risk may help prevent its occurrence, improve patient stratification, and provide insight on the underlying biological mechanisms. It remains unclear whether cerebral perivascular spaces (PVS) along with other quantitative radiographic markers of cerebral small vessel disease may help predict the risk of incident ARIA in patients diagnosed with preclinical Alzheimer's disease.MethodsParticipants from the A4 study were included. PVS and white matter hyperintensities (WMH) were segmented with robust fully-automated methods on T1-weighted and FLAIR images, respectively. Number of microhemorrhages and subcortical infarcts were previously recorded by expert radiologists. Baseline measurements of these markers were used in Cox proportional-hazards models to predict ARIA risk controlling for relevant demographic, clinical, and radiographic factors.ResultsAmong 6,028 brain MRI from 1,088 participants (median age: 71-y.o.; 59.4% women), 356 ARIA were diagnosed (median study follow-up: 5.4 years). The volume fraction of PVS and WMH, and the number of microhemorrhages at baseline predicted higher ARIA risk (adjusted hazard ratio ranges: 1.32–1.55; adjusted p-values all <0.05). Importantly, the effect of PVS on ARIA with microhemorrhages risk was observed in individuals considered at low risk of ARIA according to current guidelines, i.e., APOE-ε4 non-carriers, low WMH burden, or no microhemorrhages.ConclusionsThese results support the use of quantitative measurements of PVS in addition to WMH and microhemorrhages to assist clinicians in estimating an individual's risk of ARIA.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1743627</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1743627</link>
        <title><![CDATA[AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives]]></title>
        <pubdate>2026-04-07T00:00:00Z</pubdate>
        <category>Review</category>
        <author>Electra Chatzidimitriou</author><author>Charis Styliadis</author><author>Katherine P. Rankin</author><author>Despina Moraitou</author><author>Panagiotis Ioannidis</author><author>Panagiotis D. Bamidis</author>
        <description><![CDATA[IntroductionDementia imposes a substantial global healthcare burden, with rising prevalence and limited disease-modifying treatments. Early identification of at-risk individuals is critical for timely intervention and care planning. Magnetoencephalography (MEG) provides high-temporal-resolution measurements of neuronal activity, capturing subtle functional alterations that precede clinical symptoms. Artificial intelligence (AI), particularly machine learning (ML), can leverage MEG's rich spatiotemporal information to enhance diagnostic accuracy and dementia risk prediction. This scoping review synthesizes current evidence on AI-driven MEG analysis for the classification, prediction, and prognosis of MCI and dementia, focusing on methodological approaches, predictive performance, and translational potential.MethodsA systematic PubMed-MEDLINE search identified studies published between January 2015 and October 2025, capturing the last decade's rapid evolution of AI methodologies and their integration with neurophysiological research. Search terms combined MEG, AI, and ML with cognitive impairment and dementia. Eligible studies were peer-reviewed original research, involved human participants, employed MEG, and applied AI algorithms for classification or prediction. Extracted data included study population characteristics, MEG features, ML models, predictive biomarkers, and performance metrics.ResultsFourteen studies met eligibility criteria, covering populations from healthy controls to individuals with subjective cognitive decline, MCI, AD, and other dementias. MEG systems varied, with most studies employing 306-channel whole-head systems. ML algorithms ranged from traditional approaches, such as support vector machines and random forests, to deep learning architectures, including convolutional neural networks. Reported classification accuracies ranged from moderate (~60%) to high, with several studies achieving over 80% in distinguishing diagnostic categories or predicting MCI-to-AD progression. Key biomarkers included alterations in frequency-specific oscillatory activity, functional connectivity patterns, and large-scale network dynamics. Multimodal approaches integrating MEG with structural neuroimaging further improved predictive performance.Discussion/conclusionsDespite heterogeneity across study designs, AI-driven MEG analyses hold significant translational potential for early, non-invasive dementia prediction, enhancing diagnostic and prognostic accuracy. Advancing clinical translation will require standardized preprocessing pipelines, larger multicenter cohorts, and explainable AI frameworks. Future research should leverage next-generation MEG technologies, such as optically pumped magnetometers, to capture brain dynamics in ecologically valid, real-world scenarios. Integrating these data with AI-driven multimodal biomarkers will improve individualized risk prediction, early diagnosis, and therapeutic decision-making in dementia.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1721320</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1721320</link>
        <title><![CDATA[Treatment priorities from the perspectives of people with dementia with Lewy bodies: a reflexive thematic analysis]]></title>
        <pubdate>2026-04-01T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Paula Sinead Donnelly</author><author>Kathryn Mitchell</author><author>Noleen K. McCorry</author><author>Marco Boeri</author><author>Anthony Peter Passmore</author><author>Joseph P. M. Kane</author>
        <description><![CDATA[IntroductionTreatment priorities in dementia with Lewy bodies (DLB) have important implications for outcome selection and measurement in clinical trials and for person-centered care. The reasons underlying these priorities remain unclear. This study explored these reasons from the perspectives of people with DLB.MethodsA qualitative component was embedded within a larger stated-preference study. As part of orally administered surveys, eight people with DLB answered an open-ended question regarding which symptoms they considered most important to treat and why. Responses were analyzed using reflexive thematic analysis.ResultsSix themes were identified: (1) Cognitive and functional decline as a threat to autonomy, safety, and self, (2) Motor symptoms and pain as barriers to identity, activity, and wellbeing, (3) Autonomic symptoms as sources of stigma, shame, and disruption, (4) Sleep as a foundation for functioning in daily life, (5) Neuropsychiatric and psychological symptoms and the erosion of connection, motivation, and self, and (6) Navigating symptom complexity and uncertainty.DiscussionSymptoms were prioritized for their frequency and severity, and for the ways in which they threatened valued aspects of life, such as autonomy, safety, intimacy, and sense of self. Participants’ reasoning therefore drew attention to relatively understudied dimensions of living with DLB. Although the sample was modest, participants’ accounts provided rich insights into the lived experience of DLB and its consequences for this under-researched population. The findings provide evidence to guide outcome selection in trials and highlight the need for outcome measures that capture multidimensional domains reflecting fundamental human needs, ideally through DLB-specific instruments.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1789761</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1789761</link>
        <title><![CDATA[Pain and Nutrition in Dementia and Alzheimer’s Phase 1: a cross-sectional, observational study design]]></title>
        <pubdate>2026-03-31T00:00:00Z</pubdate>
        <category>Study Protocol</category>
        <author>Taylor C. Judkins</author><author>Hailey J. Andrews</author><author>Qianqian Song</author><author>Edward I. Clark</author><author>Camesha Tate</author><author>Joshua I. Wais</author><author>Roger Fillingim</author><author>Zhiguang Huo</author><author>Steven T. DeKosky</author><author>Barabara Gower</author><author>Ronald A. Cohen</author><author>Natalie C. Ebner</author><author>Yenisel Cruz-Almeida</author><author>Larissa J. Strath</author>
        <description><![CDATA[BackgroundNeurodegenerative diseases such as Alzheimer’s Disease and related dementias (ADRDs) as well as chronic pain have increased in prevalence as the population ages. In fact, recent epidemiological research suggests that having chronic pain may increase one’s risk of all-cause dementia. There are mechanistic factors that overlap in both ADRD and chronic pain progression, including epigenetic dysregulation that could lead to increased inflammation. Previously, our group presented evidence that dietary patterns impact inflammatory potential and epigenetic modifications, and accelerate epigenetic aging. Here, we hypothesize that diet- induced inflammation and epigenetic alterations may be underexplored mechanistic pathways connecting chronic pain and ADRD risk.MethodsThe Pain and Nutrition in Dementia and Alzheimer’s Phase 1 (PANDA-1) study is a cross-sectional, observational study, which will recruit 90 individuals ≥55 years of age with and without painful knee osteoarthritis (OA). Biological samples will be collected to assess study eligibility, blood-based inflammatory markers, and epigenetic age using the epigenetic clock DNAmGrimAge. A 24-h dietary recall will be completed to determine nutrition status via the Dietary Inflammation Index (DII). Pain and psychosocial questionnaires will be employed to determine pain phenotypes. Quantitative Sensory Testing will be conducted to determine responses to noxious mechanical and thermal stimuli. Lower-extremity function and mobility measures will also be obtained. Finally, height, weight, pain history, medical history, medication use, and demographic variables will be collected as covariates. Hierarchical regression, mediation and moderation analyses, as well as ANOVAs will be conducted to evaluate relationships among the DII, epigenetic aging, cognition status, and pain.ConclusionThis study will integrate dietary, epigenetic, and cognitive assessments in a chronic pain population, to lay the groundwork of a possible associations linking chronic pain and ADRDs. PANDA-1 aims to determine potential relationships of dietary patterns on interindividual variability of cognitive status and pain outcomes in older adults deemed cognitively intact. Subsequent phases of this study will include individuals with mild cognitive impairment and ADRDs. Findings from this work will inform future studies targeting dietary intervention approaches to mitigate overlapping neurodegenerative and pain-related aging processes.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1758361</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1758361</link>
        <title><![CDATA[Louise Snowball, room #237: exhibiting a multisensory mixed-media installation at a scientific dementia conference]]></title>
        <pubdate>2026-03-25T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Ellen Snowball</author><author>Zoe Dempster</author><author>Inbal Itzhak</author><author>Jennifer Bethell</author>
        <description><![CDATA[This article describes exhibiting an interactive art installation about dementia and long-term care at the Canadian Consortium on Neurodegeneration in Aging (CCNA) Partners Forum and Science Days (PFSD), authored from the perspectives of the artist, people with lived experience of dementia and event organizers. We outline examples of collaborating with the Engagement of People with Lived Experience of Dementia (EPLED) Advisory Group to organize the exhibit. We also report evaluation data from diverse audiences, including researchers, trainees and others, demonstrating that the artwork was a highly valued part of the scientific conference, impacting perceptions of dementia and increasing awareness of lived experience engagement in research.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1737068</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1737068</link>
        <title><![CDATA[Herpes simplex virus 2 and dementia risk: a systematic review and meta-analysis]]></title>
        <pubdate>2026-03-24T00:00:00Z</pubdate>
        <category>Systematic Review</category>
        <author>C. J. Hunt</author><author>Brinley N. Zabriskie</author><author>Ethan J. Coulter</author><author>Morgan Chase McClellan</author><author>Grace Templeton</author><author>Reagan Erbstoesser</author><author>Scott MacLean</author><author>Chris H. Miller</author><author>Jarod Moss</author><author>Caitlyn Carter</author><author>Shawn D. Gale</author><author>Jonathan D. Moore</author><author>Thomas J. Farrer</author><author>Dawson W. Hedges</author>
        <description><![CDATA[IntroductionSeveral potentially modifiable risk factors for dementia have been identified, including infectious diseases. Among the infectious diseases potentially associated with dementia is herpes simplex virus type-2 (HSV-2).MethodsTo better characterize the association between HSV-2 and dementia, we conducted a meta-analysis of published peer-reviewed studies reporting HSV-2 exposure and dementia outcomes.ResultsOf 626 identified primary studies, eight met our inclusion criteria, with one of these excluded due to overlapping data with another study, yielding seven independent studies (total N = 751,156). Meta-analyses found no significant association between HSV-2 infection and Alzheimer's disease (pooled odds ratios ≈ 1.1, 95% confidence intervals included the null across all methods). Similarly, when pooling odds ratios across studies examining all-cause dementia, results were non-significant (pooled odds ratios ≈ 1.2, 95% confidence intervals included 1). In contrast, pooled hazard ratios from three studies for all-cause dementia suggested a possible increased risk among individuals with HSV-2 (DerSimonian and Laird pooled hazard ratio = 1.37, 95% CI: 1.00–1.89; Hartung-Knapp-Sidik-Jonkman pooled hazard ratio = 1.35, 95% CI: 0.58–3.14), driven primarily by two significant studies.DiscussionOverall, the available evidence indicates no clear association between HSV-2 and Alzheimer's disease and only one of the two meta-analytic methods shows evidence of a potential relationship with all-cause dementia. These findings support continued investigation into the association between HSV-2 and dementia.]]></description>
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        <guid isPermaLink="true">https://www.frontiersin.org/articles/10.3389/frdem.2026.1772835</guid>
        <link>https://www.frontiersin.org/articles/10.3389/frdem.2026.1772835</link>
        <title><![CDATA[Farm-based therapeutic horticulture for people living with dementia: the Vicenza Farm Project]]></title>
        <pubdate>2026-03-17T00:00:00Z</pubdate>
        <category>Perspective</category>
        <author>Leonardo Dalla Costa</author><author>Francesca Meneghello</author><author>Costantina Righetto</author><author>Giulio Senes</author>
        <description><![CDATA[Dementia is a major global health challenge, with wide-ranging psychosocial and relational impacts that call for supportive, everyday interventions alongside clinical care. While advances in Alzheimer’s disease are promising, dementia includes multiple conditions, including young-onset forms, and existing pharmacological and non-pharmacological interventions still offer valuable but incomplete support, often leaving everyday psychosocial needs unmet for most people living with dementia. This Perspective describes the Vicenza Farm Project, a farm-based therapeutic horticulture program developed on social and educational farms of Northern Italy. The program offers weekly 3-h group sessions from March to October for around 8–10 participants, including people with young-onset dementia, facilitated by a multidisciplinary team of farmers, psychologists and trained volunteers. Activities follow a structured, replicable protocol that combines cognitive stimulation, seasonal gardening and farm tasks, shared breaks and closing reflection, with an emphasis on supported participation, personal agency and safe freedom. Drawing on qualitative and quantitative data from international literature on nature-based and care farming interventions, we outline how a farm-based therapeutic horticulture can help restore purpose, social connection and embodied identity while also animating rural spaces and reinforcing environmentally sensitive farming practices. We contrast the Italian policy framework of social agriculture, in which therapeutic horticulture is not yet recognized as a health intervention, with the more institutionalized Dutch model of green care farms, and we propose priorities for evaluation, integration into dementia pathways and long-term funding.]]></description>
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