AUTHOR=Toz-Akalin Tugba , Öztürk-Bozkurt Funda , Kusdemir Mahmut , Özsoy Alev , Yüzbaşıoğlu Emir , Özcan Mutlu TITLE=Three-year clinical performance of direct restorations using low-shrinkage Giomer vs. nano-hybrid resin composite JOURNAL=Frontiers in Dental Medicine VOLUME=Volume 5 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/dental-medicine/articles/10.3389/fdmed.2024.1459473 DOI=10.3389/fdmed.2024.1459473 ISSN=2673-4915 ABSTRACT=Objectives: The objective of this investigation was to compare the clinical performances of a nano-hybrid resin composites and low-shrinkage Giomer resin composite.Material and Methods: Totally, 35 pairs of restorations performed with either low-shrinkage Giomer (Beautifil II LS, Shofu Inc.) or nano-hybrid (Clearfil Majesty Posterior) resin composites in 35 patients by two operators using the relevant adhesives: FL-Bond II (Shofu Inc) and Clearfil SE Bond (Kuraray), with self-etching technique according to each manufacturer's instructions. Two clinicians assessed the restorations two weeks after restorative procedures (baseline), after six months, one, two and three years using FDI criteria (Scores 1-5). Data were analyzed using the marginal homogeneity and the McNemar test. Survival Rate was calculated using Kaplan-Meier survival analysis and the survival of the two groups was compared with the Log-Rank test (p=0.05).Results: Mean observation period was 37.7±6.8 months. All restorations completed their 3-years follow up. All criteria were rated mainly with high (1 or 2) scores for quality in both groups. Only one restoration from lowshrinkage Giomer resin composite group was accepted as failure at two-year recall due to retention loss. Conclusion: Over the three-year follow-up, both the Giomer and the nano-hybrid resin composite restorations' performances were similar and clinically acceptable.Clinical Relevance: Low-shrinkage Giomer resin composite exhibited similar clinical performance to the nanohybrid resin composite after three years in service, with both materials displaying minor surface deteriorations at three-year recall.Clinical Trial Registration Number: NCT02823769.