AUTHOR=Yu Jiaao , Cheong Io Hong , Kozlakidis Zisis , Wang Hui TITLE=Advancements and challenges of artificial intelligence in dermatology: a review of applications and perspectives in China JOURNAL=Frontiers in Digital Health VOLUME=Volume 7 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1544520 DOI=10.3389/fdgth.2025.1544520 ISSN=2673-253X ABSTRACT=The diagnosis of skin diseases can be challenging due to their diverse manifestations, while early detection of malignant skin cancers greatly improves the prognosis, highlighting the pressing need for efficient screening methods. In recent years, advancements in AI have paved the way for AI-aided diagnosis of skin lesions. Furthermore, the COVID-19 pandemic has spurred the demand of telemedicine, accelerating the integration of AI into medical domains, particularly in China. This article aims to provide an overview of the progress of AI-aided diagnosis in Chinese dermatology. Given the widespread use of public datasets in the reviewed studies, we compared the performance of AI models in segmentation and classification on public datasets. Despite the promising results of AI in experimental settings, we recognize the limitations of these public datasets in representing clinical scenarios in China. To address this gap, we reviewed the studies that used clinical datasets and conducted comparative analyses between AI and dermatologists. Although AI demonstrated comparable results to human experts, AI still cannot replace dermatologists due to limitations in generalizability and interpretability. We attempt to provide insights into improving the performance of AI through advancements in dataset quality, image pre-processing techniques, and integration of medical data. Finally, the role that AI will play in the medical practice and the relationship between AI and dermatologists are discussed. This systematic review addresses the gap in evaluating AI applications in Chinese dermatology, with a focus on dermatological datasets and real-world application.