AUTHOR=Saratkar Saniya Y. , Langote Meher , Kumar Praveen , Gote Pradnyawant , Weerarathna Induni Nayodhara , Mishra Gaurav V. 

TITLE=Digital twin for personalized medicine development

JOURNAL=Frontiers in Digital Health

VOLUME=Volume 7 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1583466

DOI=10.3389/fdgth.2025.1583466

ISSN=2673-253X

ABSTRACT=Digital Twin (DT) technology is revolutionizing healthcare by enabling real-time monitoring, predictive analytics, and highly personalized medical care. As a key innovation of Industry 4.0, DTs integrate advanced tools like artificial intelligence (AI), the Internet of Things (IoT), and machine learning (ML) to create dynamic, data-driven replicas of patients. These digital replicas allow simulations of disease progression, optimize diagnostics, and personalize treatment plans based on individual genetic and lifestyle profiles. This review explores the evolution, architecture, and enabling technologies of DTs, focusing on their transformative applications in personalized medicine (PM). While the integration of DTs offers immense potential to improve outcomes and efficiency in healthcare, challenges such as data privacy, system interoperability, and ethical concerns must be addressed. The paper concludes by highlighting future directions, where AI, cloud computing, and blockchain are expected to play a pivotal role in overcoming these limitations and advancing precision medicine.