AUTHOR=Švihrová Radoslava , Marzorati Davide , Bechný Michal , Grossenbacher Max , Ilchenko Yuriy , Grossenbacher Jürg , Tzovara Athina , Faraci Francesca Dalia TITLE=Toward burnout prevention with Bayesian mixed-effects regression analysis of longitudinal data from wearables: a preliminary study JOURNAL=Frontiers in Digital Health VOLUME=Volume 7 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1640900 DOI=10.3389/fdgth.2025.1640900 ISSN=2673-253X ABSTRACT=Wearable devices have gained significant popularity in recent years, as they provide valuable insights into behavioral patterns and enable unobtrusive continuous monitoring. This work explores how daily lifestyle choices and physiological factors contribute to coping capacities and aims at designing burnout prevention systems. Key variables examined include sleep stage proportions and nocturnal stress levels, as both play a crucial role in recovery and resilience. Longitudinal data from a 1-week study incorporating wearable-derived features and contextual information are analyzed using a mixed-effects model, accounting for both overall trends and individual differences. A Bayesian inference approach is exploited to quantify uncertainty in estimated effects, providing their probabilistic interpretation and ensuring robustness despite the low sample size. Findings indicate that alcohol consumption negatively affects rapid-eye-movement sleep, increases awake time, and elevates nocturnal stress. Excessive daily stress reduces deep sleep, while an increase in daily active hours promote it. These results align with the existing literature, demonstrating the potential of consumer-grade wearables to monitor clinically relevant relationships and guide interventions for stress reduction and burnout prevention.